RAD52 and ERCC4

Data Source:
HPRD (in vitro, in vivo)

		RAD52	ERCC4
Description		RAD52 homolog, DNA repair protein	ERCC excision repair 4, endonuclease catalytic subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm ERCC4-ERCC1 Complex
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding Identical Protein Binding	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding Telomerase Inhibitor Activity Identical Protein Binding Protein N-terminus Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Double-strand Break Repair DNA Recombination Mitotic Recombination Cellular Response To DNA Damage Stimulus DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Oxidative Stress Double-strand Break Repair Via Single-strand Annealing Regulation Of Nucleotide-excision Repair	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Via Nonhomologous End Joining Response To UV UV Protection Regulation Of Autophagy Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Cellular Response To UV Interstrand Cross-link Repair Negative Regulation Of Telomerase Activity Telomeric DNA-containing Double Minutes Formation Global Genome Nucleotide-excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protection From Non-homologous End Joining At Telomere Negative Regulation Of Double-stranded Telomeric DNA Binding
Pathways		SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA)	HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Blood protein levels ( 29875488) Body mass index ( 26426971) Eosinophil percentage of granulocytes ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lung cancer ( 22899653) Neutrophil percentage of granulocytes ( 27863252) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418) Youthful appearance (self-reported) ( 32339537)	Alcohol consumption (drinks per week) ( 30643258) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Bilirubin levels ( 22085899) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Bitter alcoholic beverage consumption ( 31046077) Bone mineral density (total hip) ( 29883787) Conduct disorder (symptom count) ( 20585324) Egg allergy ( 25710614) Emphysema imaging phenotypes ( 26030696) Metabolic syndrome ( 20694148) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 31170924)
Interacting Genes		25 interacting genes: ABL1 AURKB DCP1A ERCC1 ERCC2 ERCC3 ERCC4 KPNA3 KPNA5 MCM2 MCM3 MEOX1 MEOX2 NFYC PAX5 PLK3 RAD51 RDM1 RPA1 RPA2 SEM1 SUMO1 TTK UBE2I WRN	13 interacting genes: ERCC1 FANCG GTF2H1 KIF11 RAD52 RPA1 RPA2 SLX1A SLX4 SPTAN1 SUMO2 TACC1 XPA
Entrez ID		5893	2072
HPRD ID		11855	00594
Ensembl ID		ENSG00000002016	ENSG00000175595
Uniprot IDs		B7Z2G8 B7Z5Q6 F5GX32 P43351 Q5DR82	A0A1W1GSK9 B4DXD8 Q92889
PDB IDs		1H2I 1KN0 5JRB 5XRZ 5XS0	1Z00 2A1J 2AQ0 2KN7 2MUT 6SXA 6SXB
Enriched GO Terms of Interacting Partners?
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