PPM1A and NR4A1

Data Source:
BioGRID (two hybrid)

		PPM1A	NR4A1
Description		protein phosphatase, Mg2+/Mn2+ dependent 1A	nuclear receptor subfamily 4 group A member 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Membrane	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrion Cytosol Nuclear Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity R-SMAD Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Zinc Ion Binding Glucocorticoid Receptor Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation N-terminal Protein Myristoylation Cell Cycle Arrest Negative Regulation Of SMAD Protein Complex Assembly Dephosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Peptidyl-threonine Dephosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Export From Nucleus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Intracellular Receptor Signaling Pathway Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Fat Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Energy dependent regulation of mTOR by LKB1-AMPK	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases
GWAS		Allergic rhinitis ( 22036096) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hair color ( 29662168) Hip circumference adjusted for BMI ( 25673412) Menarche (age at onset) ( 27182965) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		37 interacting genes: AATK AKT1 ALK CACNA1A CACNA1B CACNA1C CDC42BPA CDC42BPB CTNNB1 DVL1 DVL2 DVL3 EEF2 EGFR ERBB2 ERBB3 ERBB4 FGFR2 GRM3 HSPB1 IGF1R KDR LMTK2 MSN NR4A1 PAK1 PAK2 PIK3R1 PLK3 PRKAA1 PRKCA PRKCD PTK7 ROR2 RPLP0 SMAD2 SMAD3	87 interacting genes: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATM ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NDRG1 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRA RXRG SERPINA4 SERPING1 SMAD3 SOCS4 STAT3 SUGT1 TCF4 TP53 TRAF2 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579
Entrez ID		5494	3164
HPRD ID		16199	00744
Ensembl ID		ENSG00000100614	ENSG00000123358
Uniprot IDs		A0A024R6A5 B2R8E4 P35813	A0A024R126 F5GXF0 P22736 Q6ZMM6
PDB IDs		1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG 6B67	2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG 6KZ5 6LC1
Enriched GO Terms of Interacting Partners?
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