PPM1A and GRM3

Data Source:
HPRD (in vitro)

		PPM1A	GRM3
Description		protein phosphatase, Mg2+/Mn2+ dependent 1A	glutamate metabotropic receptor 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Membrane	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Dendritic Spine Astrocyte Projection Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding Calmodulin-dependent Protein Phosphatase Activity R-SMAD Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation N-terminal Protein Myristoylation Cell Cycle Arrest Negative Regulation Of SMAD Protein Complex Assembly Dephosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Peptidyl-threonine Dephosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Export From Nucleus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Regulation Of Synaptic Transmission, Glutamatergic
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Energy dependent regulation of mTOR by LKB1-AMPK	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			LY2140023
Diseases
GWAS		Allergic rhinitis ( 22036096) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hair color ( 29662168) Hip circumference adjusted for BMI ( 25673412) Menarche (age at onset) ( 27182965) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 27611488) Autism spectrum disorder or schizophrenia ( 28540026) Brachial circumference ( 22479309) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Feeling worry ( 29500382) Hand grip strength (Mahalanobis distance) ( 32235003) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Seborrheic dermatitis ( 29203360) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		37 interacting genes: AATK AKT1 ALK CACNA1A CACNA1B CACNA1C CDC42BPA CDC42BPB CTNNB1 DVL1 DVL2 DVL3 EEF2 EGFR ERBB2 ERBB3 ERBB4 FGFR2 GRM3 HSPB1 IGF1R KDR LMTK2 MSN NR4A1 PAK1 PAK2 PIK3R1 PLK3 PRKAA1 PRKCA PRKCD PTK7 ROR2 RPLP0 SMAD2 SMAD3	6 interacting genes: CALM1 GRIP1 PICK1 PPM1A SDCBP TAMALIN
Entrez ID		5494	2913
HPRD ID		16199	03070
Ensembl ID		ENSG00000100614	ENSG00000198822
Uniprot IDs		A0A024R6A5 B2R8E4 P35813	A4D1D0 Q14832
PDB IDs		1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG 6B67	1S8M 3SM9 4XAR 5CNK 5CNM 6B7H
Enriched GO Terms of Interacting Partners?
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