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SH2D1B and TNK2
Data Source:
BioGRID
(two hybrid)
SH2D1B
TNK2
Description
SH2 domain containing 1B
tyrosine kinase non receptor 2
Image
GO Annotations
Cellular Component
Cytosol
Nucleus
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Adherens Junction
Membrane
Clathrin-coated Vesicle
Cytoplasmic Vesicle Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Perinuclear Region Of Cytoplasm
Grb2-EGFR Complex
Cytoophidium
Molecular Function
Protein Binding
Protein-macromolecule Adaptor Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
GTPase Inhibitor Activity
Signaling Receptor Binding
Epidermal Growth Factor Receptor Binding
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
WW Domain Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Adaptive Immune Response
Leukocyte Activation Involved In Immune Response
Positive Regulation Of Natural Killer Cell Mediated Immunity
Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Immune Response
Endocytosis
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Small GTPase Mediated Signal Transduction
Phosphorylation
Cell Differentiation
Negative Regulation Of GTPase Activity
Innate Immune Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Clathrin-dependent Endocytosis
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
ATP
Debromohymenialdisine
Entrectinib
Fostamatinib
Diseases
GWAS
Sum of carotid plaque area (
32469969
)
Sum of stenosis (
32469969
)
Takayasu arteritis (
25604533
)
Asthma (
31959851
)
Bronchopulmonary dysplasia (
23897914
)
Low density lipoprotein cholesterol levels (
30498476
)
Total cholesterol levels (
30498476
)
Interacting Genes
25 interacting genes:
AGR2
APP
AR
BLK
CD244
CD84
EGFR
ERBB2
ERBB3
ERBB4
GAB1
KIT
LY9
MAGEB4
MAPK8IP2
MEOX2
MET
NFKBID
NUTM1
PRDX1
PTK2
SLAMF1
STAT4
TNK2
TRIM54
49 interacting genes:
AKT1
AQP1
AR
ARSL
BAG3
CDC42
CLTC
CSPG4
CTTN
CYSRT1
DPH2
EGFR
FGFR1
FYN
GALT
GRB2
HCK
HECW1
HSH2D
HSP90AB2P
ITFG2
KCNA5
KRTAP10-3
MAGI3
MCF2
MERTK
NCK1
NEK6
NOTCH2NLA
NPHP1
PDGFRB
PIK3R3
RASGEF1C
RASGRF1
RPL18A
SEZ6
SH2D1A
SH2D1B
SIAH1
SMURF1
SNX9
SOCS4
SRC
SRSF5
VTI1B
WAS
WWOX
WWP2
YES1
Entrez ID
117157
10188
HPRD ID
12248
06104
Ensembl ID
ENSG00000198574
ENSG00000061938
Uniprot IDs
O14796
A0A499FJ16
A0A5F9ZGX5
A0A5F9ZHJ2
B3KXJ4
C9J1X3
Q07912
PDB IDs
5KAZ
1CF4
1U46
1U4D
1U54
3EQP
3EQR
4EWH
4HZR
4HZS
4ID7
5ZXB
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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