SH2D1B and CD244

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SH2D1B	CD244
Description		SH2 domain containing 1B	CD244 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding Signaling Receptor Activity MHC Class I Protein Binding
	Biological Process	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Immune Response	Adaptive Immune Response Natural Killer Cell Activation Involved In Immune Response Signal Transduction Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Innate Immune Response Leukocyte Migration Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Granzyme B Production
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)	Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54	5 interacting genes: ARHGEF7 CD247 CD48 LAT SH2D1B
Entrez ID		117157	51744
HPRD ID		12248	16121
Ensembl ID		ENSG00000198574	ENSG00000122223
Uniprot IDs		O14796	Q9BZW8
PDB IDs		5KAZ
Enriched GO Terms of Interacting Partners?
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