LYST and ESS2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		LYST	ESS2
Description		lysosomal trafficking regulator	ess-2 splicing factor homolog
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Microtubule Cytoskeleton Membrane	Nucleus Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Protein Kinase Binding	Molecular_function Protein Binding
	Biological Process	Phagocytosis Lysosome Organization Protein Localization Protein Transport Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus	MRNA Splicing, Via Spliceosome Nervous System Development
Pathways
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Basophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Systemic lupus erythematosus ( 26502338 19838195)
Interacting Genes		24 interacting genes: ATN1 CALM1 CELF4 CENPJ CNTROB CSNK2B DNAJC14 EFS ESRRA ESS2 HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ YWHAZ ZNF521	18 interacting genes: ARMC7 CCDC57 CDK5RAP3 CRP DGCR6 DHX16 EXOC8 FRA10AC1 LYST OIP5 PFDN1 QARS1 RACK1 RBM4 SMARCD1 TTC14 VIM WNK2
Entrez ID		1130	8220
HPRD ID		06060	03452
Ensembl ID		ENSG00000143669	ENSG00000100056
Uniprot IDs		Q99698	F8WEF8 Q96DF8
PDB IDs
Enriched GO Terms of Interacting Partners?
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