ESS2 and WNK2

Data Source:
BioGRID (two hybrid)

		ESS2	WNK2
Description		ess-2 splicing factor homolog	WNK lysine deficient protein kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Catalytic Step 2 Spliceosome	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Serine/threonine Kinase Activity ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Nervous System Development	Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Sodium Ion Transport Intracellular Signal Transduction Protein Autophosphorylation Ion Homeostasis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Stimuli-sensing channels
Drugs
Diseases
GWAS			Ability to confide in someone ( 29970889) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Perceived sweetness of sucrose ( 31005972)
Interacting Genes		18 interacting genes: ARMC7 CCDC57 CDK5RAP3 CRP DGCR6 DHX16 EXOC8 FRA10AC1 LYST OIP5 PFDN1 QARS1 RACK1 RBM4 SMARCD1 TTC14 VIM WNK2	5 interacting genes: ATXN1 ESS2 MTDH WNK1 YWHAZ
Entrez ID		8220	65268
HPRD ID		03452	06951
Ensembl ID		ENSG00000100056	ENSG00000165238
Uniprot IDs		F8WEF8 Q96DF8	F8W9F9 Q9Y3S1
PDB IDs			6ELM 6FBK
Enriched GO Terms of Interacting Partners?
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