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LYST and CENPJ
Data Source:
BioGRID
(two hybrid)
LYST
CENPJ
Description
lysosomal trafficking regulator
centromere protein J
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Microtubule Cytoskeleton
Membrane
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Centriole
Cytosol
Microtubule
Plasma Membrane
Gamma-tubulin Small Complex
Molecular Function
Protein Binding
Protein Kinase Binding
Transcription Coactivator Activity
Protein Binding
Tubulin Binding
Protein Kinase Binding
Protein Domain Specific Binding
Identical Protein Binding
Gamma-tubulin Binding
Biological Process
Phagocytosis
Lysosome Organization
Protein Localization
Protein Transport
Leukocyte Chemotaxis
Melanosome Organization
Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway
Mast Cell Secretory Granule Organization
Natural Killer Cell Mediated Cytotoxicity
Defense Response To Bacterium
Defense Response To Protozoan
Pigmentation
Defense Response To Virus
G2/M Transition Of Mitotic Cell Cycle
Microtubule Nucleation
Centriole Replication
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Astral Microtubule Nucleation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Centriole Replication
Microtubule Polymerization
Cell Division
Cilium Assembly
Centriole Elongation
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Centriole Elongation
Positive Regulation Of Establishment Of Protein Localization
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
AURKA Activation by TPX2
Drugs
Diseases
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
Seckel syndrome
Primary microcephaly (MCPH)
GWAS
Basophil percentage of white cells (
32888494
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Systemic lupus erythematosus (
26502338
19838195
)
Interacting Genes
24 interacting genes:
ATN1
CALM1
CELF4
CENPJ
CNTROB
CSNK2B
DNAJC14
EFS
ESRRA
ESS2
HGS
HNRNPM
KPNB1
MED12
MRPL17
MRPS31
NCDN
PCBP4
TNNI3
VTA1
YWHAB
YWHAQ
YWHAZ
ZNF521
15 interacting genes:
ATN1
BCCIP
CIC
CREBBP
EPB41
FBXO7
GFI1B
LAG3
LYST
MTDH
STAT5A
STAT5B
TUBG1
YWHAG
YWHAZ
Entrez ID
1130
55835
HPRD ID
06060
09876
Ensembl ID
ENSG00000143669
ENSG00000151849
Uniprot IDs
Q99698
A8K8P1
F6VUX8
Q9HC77
PDB IDs
5EIB
5ITZ
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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