LYST and CELF4

Data Source:
BioGRID (two hybrid)

		LYST	CELF4
Description		lysosomal trafficking regulator	CUGBP Elav-like family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Microtubule Cytoskeleton Membrane	Nucleus Nucleoplasm Cytoplasm Ribonucleoprotein Complex
	Molecular Function	Protein Binding Protein Kinase Binding	Translation Repressor Activity, MRNA Regulatory Element Binding RNA Binding MRNA Binding Pre-mRNA Binding BRE Binding
	Biological Process	Phagocytosis Lysosome Organization Protein Localization Protein Transport Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Splice Site Selection Germ Cell Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Translation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Retina Development In Camera-type Eye
Pathways
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Basophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Systemic lupus erythematosus ( 26502338 19838195)	Body fat mass ( 28552196) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Educational attainment ( 25201988) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling guilty ( 29500382) Feeling hurt ( 29500382) Feeling miserable ( 29500382) General factor of neuroticism ( 30867560) Household income ( 31844048) Household income (MTAG) ( 31844048) Mood instability ( 31168069) Neurociticism ( 29500382) Neuroticism ( 27089181 27067015) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		24 interacting genes: ATN1 CALM1 CELF4 CENPJ CNTROB CSNK2B DNAJC14 EFS ESRRA ESS2 HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ YWHAZ ZNF521	10 interacting genes: APP LYST PCBP3 PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS2 TIAL1
Entrez ID		1130	56853
HPRD ID		06060	12534
Ensembl ID		ENSG00000143669	ENSG00000101489
Uniprot IDs		Q99698	Q9BZC1
PDB IDs			2DGP 2DNK
Enriched GO Terms of Interacting Partners?
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