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TREX1 and GJA5
Data Source:
BioGRID
(two hybrid)
TREX1
GJA5
Description
three prime repair exonuclease 1
gap junction protein alpha 5
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nuclear Envelope
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Oligosaccharyltransferase Complex
Protein-DNA Complex
Nuclear Replication Fork
Integral Component Of Plasma Membrane
Gap Junction
Connexin Complex
Intercalated Disc
Cell Projection
Molecular Function
Magnesium Ion Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
3'-5'-exodeoxyribonuclease Activity
DNA Binding, Bending
3'-5' Exonuclease Activity
Exodeoxyribonuclease III Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Adenyl Deoxyribonucleotide Binding
Protein Homodimerization Activity
Metal Ion Binding
WW Domain Binding
Gap Junction Channel Activity
Protein Binding
Gap Junction Hemi-channel Activity
Connexin Binding
Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling
Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling
Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling
Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling
Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling
Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling
Disordered Domain Specific Binding
Biological Process
DNA Catabolic Process, Exonucleolytic
Blood Vessel Development
Kidney Development
Activation Of Immune Response
Macrophage Activation Involved In Immune Response
Lymphoid Progenitor Cell Differentiation
Immune Response In Brain Or Nervous System
Inflammatory Response To Antigenic Stimulus
T Cell Antigen Processing And Presentation
Regulation Of Immunoglobulin Production
Heart Morphogenesis
Heart Process
Atrial Cardiac Muscle Tissue Development
Generation Of Precursor Metabolites And Energy
Regulation Of Glycolytic Process
DNA Metabolic Process
DNA Replication
DNA Repair
Mismatch Repair
DNA Modification
DNA Recombination
Determination Of Adult Lifespan
Regulation Of Fatty Acid Metabolic Process
Transposition, RNA-mediated
Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Regulation Of Tumor Necrosis Factor Production
Cellular Response To Reactive Oxygen Species
Cellular Response To Interferon-beta
CD86 Biosynthetic Process
Apoptotic Cell Clearance
Regulation Of Cellular Respiration
Establishment Of Protein Localization
Regulation Of Lipid Biosynthetic Process
Regulation Of Inflammatory Response
Regulation Of Catalytic Activity
Protein Stabilization
Regulation Of T Cell Activation
Defense Response To Virus
Type I Interferon Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of Protein Complex Stability
Cellular Response To Gamma Radiation
Detection Of Stimulus Involved In Cell Cycle Checkpoint
Detection Of DNA Damage Stimulus Involved In DNA Damage Checkpoint
Signal Transduction Involved In DNA Damage Checkpoint
Cellular Response To Hydroxyurea
Immune Complex Formation
DNA Synthesis Involved In UV-damage Excision Repair
Regulation Of Lysosome Organization
Angiogenesis
Negative Regulation Of Glomerular Filtration
Outflow Tract Morphogenesis
Endothelium Development
Mitral Valve Development
Pulmonary Valve Formation
Ventricular Septum Development
Atrial Septum Development
Potassium Ion Transport
Cell-cell Signaling
Cell Communication By Chemical Coupling
Regulation Of Cell Communication By Electrical Coupling
Positive Regulation Of Cell Communication By Chemical Coupling
Gap Junction Assembly
Negative Regulation Of Blood Pressure
Positive Regulation Of Vasoconstriction
Artery Morphogenesis
Transmembrane Transport
Regulation Of Cardiac Muscle Contraction
Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization
SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling
Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling
AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling
Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling
Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Regulation Of AV Node Cell Action Potential
Regulation Of Bundle Of His Cell Action Potential
Regulation Of Purkinje Myocyte Action Potential
Regulation Of Atrial Cardiac Muscle Cell Action Potential
Vasomotion
Pathways
Regulation by TREX1
IRF3-mediated induction of type I IFN
Gap junction assembly
Drugs
Diseases
Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE)
Aicardi-Goutieres Syndrome (AGS)
Retinal vasculopathy with cerebral leukodystrophy (RVCL)
Atrial fibrillation
GWAS
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Obesity-related traits (
23251661
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Atrial fibrillation (
30061737
29892015
)
Cognitive performance (
20125193
)
Methotrexate-induced interstitial lung disease in rheumatoid arthritis (
28500057
)
PR interval (
32439900
)
Interacting Genes
46 interacting genes:
AQP6
ATM
ATR
CD81
CHCHD2
CLDN22
CRB3
CYB561
CYSRT1
EBP
ELOVL4
FAM174A
FFAR3
FNDC9
GJA5
GKN1
GPR42
HSD17B13
IFNGR2
IFT20
JAGN1
KRTAP10-7
MCM7
MFSD14B
MSH2
NBN
PEX12
PRKDC
PRND
RELL1
RIBC2
RNASEK
RPA1
SEC11C
SET
SLC10A6
SLC22A2
SLC7A14
TM4SF18
TMEM205
TMEM207
TMEM45B
TMEM86B
TMX2
UBQLN1
VKORC1
34 interacting genes:
AAR2
ABHD16A
BLCAP
C4orf3
EMP3
FCER1G
GJA1
GJB2
IGFBP5
LEPROT
LEPROTL1
LHFPL2
MARK1
MFSD5
MS4A13
NIPAL3
NKG7
PGAP2
PRAF2
PRKACA
RIMS3
RPRM
SLC13A4
SLC30A2
SLC35F1
SLC41A1
SLC41A2
SLC66A1
TMBIM6
TMEM107
TREX1
UBQLN4
VRK2
YIPF6
Entrez ID
11277
2702
HPRD ID
09423
08699
Ensembl ID
ENSG00000213689
ENSG00000265107
Uniprot IDs
Q5TZT0
Q9NSU2
P36382
X5D2H9
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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