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TREX1 and JAGN1
Data Source:
BioGRID
(two hybrid)
TREX1
JAGN1
Description
three prime repair exonuclease 1
jagunal homolog 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nuclear Envelope
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Oligosaccharyltransferase Complex
Protein-DNA Complex
Nuclear Replication Fork
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Molecular Function
Magnesium Ion Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
3'-5'-exodeoxyribonuclease Activity
DNA Binding, Bending
3'-5' Exonuclease Activity
Exodeoxyribonuclease III Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Adenyl Deoxyribonucleotide Binding
Protein Homodimerization Activity
Metal Ion Binding
WW Domain Binding
Protein Binding
Biological Process
DNA Catabolic Process, Exonucleolytic
Blood Vessel Development
Kidney Development
Activation Of Immune Response
Macrophage Activation Involved In Immune Response
Lymphoid Progenitor Cell Differentiation
Immune Response In Brain Or Nervous System
Inflammatory Response To Antigenic Stimulus
T Cell Antigen Processing And Presentation
Regulation Of Immunoglobulin Production
Heart Morphogenesis
Heart Process
Atrial Cardiac Muscle Tissue Development
Generation Of Precursor Metabolites And Energy
Regulation Of Glycolytic Process
DNA Metabolic Process
DNA Replication
DNA Repair
Mismatch Repair
DNA Modification
DNA Recombination
Determination Of Adult Lifespan
Regulation Of Fatty Acid Metabolic Process
Transposition, RNA-mediated
Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Regulation Of Tumor Necrosis Factor Production
Cellular Response To Reactive Oxygen Species
Cellular Response To Interferon-beta
CD86 Biosynthetic Process
Apoptotic Cell Clearance
Regulation Of Cellular Respiration
Establishment Of Protein Localization
Regulation Of Lipid Biosynthetic Process
Regulation Of Inflammatory Response
Regulation Of Catalytic Activity
Protein Stabilization
Regulation Of T Cell Activation
Defense Response To Virus
Type I Interferon Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of Protein Complex Stability
Cellular Response To Gamma Radiation
Detection Of Stimulus Involved In Cell Cycle Checkpoint
Detection Of DNA Damage Stimulus Involved In DNA Damage Checkpoint
Signal Transduction Involved In DNA Damage Checkpoint
Cellular Response To Hydroxyurea
Immune Complex Formation
DNA Synthesis Involved In UV-damage Excision Repair
Regulation Of Lysosome Organization
Neutrophil Mediated Immunity
Exocytosis
Endoplasmic Reticulum Organization
Protein Transport
Vesicle-mediated Transport
Neutrophil Differentiation
Granulocyte Colony-stimulating Factor Signaling Pathway
Defense Response To Fungus
Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Cellular Response To Tunicamycin
Neutrophil Migration
Pathways
Regulation by TREX1
IRF3-mediated induction of type I IFN
Drugs
Diseases
Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE)
Aicardi-Goutieres Syndrome (AGS)
Retinal vasculopathy with cerebral leukodystrophy (RVCL)
GWAS
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Obesity-related traits (
23251661
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Interacting Genes
46 interacting genes:
AQP6
ATM
ATR
CD81
CHCHD2
CLDN22
CRB3
CYB561
CYSRT1
EBP
ELOVL4
FAM174A
FFAR3
FNDC9
GJA5
GKN1
GPR42
HSD17B13
IFNGR2
IFT20
JAGN1
KRTAP10-7
MCM7
MFSD14B
MSH2
NBN
PEX12
PRKDC
PRND
RELL1
RIBC2
RNASEK
RPA1
SEC11C
SET
SLC10A6
SLC22A2
SLC7A14
TM4SF18
TMEM205
TMEM207
TMEM45B
TMEM86B
TMX2
UBQLN1
VKORC1
126 interacting genes:
AGPAT4
APP
AQP6
ARL13B
BCL2L13
BET1
BMP10
BNIP1
BNIP3
BSND
BTNL9
C4orf3
CALHM6
CCL4L2
CD79A
CDIPT
CERS4
CGRRF1
CLDN7
CLEC12B
CLEC4D
CLEC7A
CMTM5
COX20
CREB3L1
CYBC1
CYP4F2
DNAJC30
EBP
EDA2R
EHHADH
ELOVL4
ERG28
ERGIC3
F11R
FAM177A1
FAM209A
FCGR1A
FCRL2
FCRL4
FDFT1
FIS1
FKBP8
FNDC9
FRMD3
FXYD6
GIMAP1
GIMAP5
GJB5
GOLM1
GOSR2
GP2
GPR152
GPR37L1
HMOX1
HSD17B13
HTATIP2
ICMT
IER3IP1
IFNGR2
IL3RA
KASH5
KCNA1
KIR2DL3
KIR3DL3
LEMD1
LHFPL5
LMNA
LPAR3
MFF
MRM3
MTIF3
NINJ2
NRG1
OTULINL
PDZK1IP1
PLP1
PLPP2
PSCA
RETREG3
RTP2
SACM1L
SAR1A
SCD
SEC22B
SERP1
SLAMF6
SLC16A2
SLC23A2
SLC34A2
SMAGP
SMIM1
SMIM19
STOML3
STX1A
STX3
STX5
STX7
STX8
TECR
TIMM23
TMEM100
TMEM106C
TMEM120B
TMEM128
TMEM14B
TMEM199
TMEM207
TMEM237
TMEM242
TMEM243
TMEM52B
TMEM65
TMIE
TNFSF14
TREX1
TSNARE1
UBE2J1
USE1
VAMP2
VAMP5
VAPA
VAPB
VKORC1
VSIG4
VTI1B
Entrez ID
11277
84522
HPRD ID
09423
13749
Ensembl ID
ENSG00000213689
ENSG00000171135
Uniprot IDs
Q5TZT0
Q9NSU2
Q8N5M9
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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