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EGLN3 and SUMO3
Data Source:
BioGRID
(enzymatic study)
EGLN3
SUMO3
Description
egl-9 family hypoxia inducible factor 3
small ubiquitin like modifier 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
PML Body
Molecular Function
Protein Binding
Ferrous Iron Binding
2-oxoglutarate-dependent Dioxygenase Activity
L-ascorbic Acid Binding
Peptidyl-proline Dioxygenase Activity
Peptidyl-proline 4-dioxygenase Activity
Protein Binding
Protein Tag
Ubiquitin-like Protein Ligase Binding
Biological Process
Response To Hypoxia
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Protein Hydroxylation
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Regulation Of Cell Population Proliferation
Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Protein Sumoylation
Negative Regulation Of DNA Binding
Regulation Of Protein Localization To Nucleus
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Formation of Incision Complex in GG-NER
Drugs
Ascorbic acid
Roxadustat
Diseases
GWAS
Alzheimer's disease (late onset) (
30820047
)
Daytime sleep phenotypes (
27126917
)
Hematocrit (
32888494
27863252
)
Hemoglobin (
32888494
)
Red blood cell count (
32888494
)
Delirium (
29631748
)
Interacting Genes
38 interacting genes:
ABI2
ADRB2
ATF4
CTBP2
DUSP7
EFHC2
EPAS1
EPOR
FAM168B
FOXJ2
GSC2
HIF1A
HIF3A
IK
IKBKG
IKZF3
LDB2
LNX1
MAPK1
MAPK7
MDM2
NCAPH2
NTAQ1
OS9
PKM
PLEKHA2
PRPF19
RBBP8NL
SERTAD1
SIAH2
SUMO1
SUMO2
SUMO3
TP53
TTC23L
WDR83
ZC2HC1A
ZNF655
53 interacting genes:
ANXA7
BLM
CCNE2
CDKN1A
CEBPA
CHAF1A
CUL3
DAXX
EGLN3
FAM221A
FOS
HIPK2
HOMEZ
HSF1
HSF2
JUN
KALRN
MAPKAPK3
PFDN1
PIAS1
PIAS2
PIAS3
PIAS4
PML
RANGAP1
RNF111
RNF8
SAE1
SENP1
SENP2
SENP5
SMN1
SOX10
SOX6
SP100
TDG
TDP2
TK1
TP53BP2
TTR
UBA2
UBE2I
UBE3A
UPF2
USP25
USPL1
VIM
WWTR1
YAP1
ZBTB33
ZBTB39
ZCCHC12
ZNF496
Entrez ID
112399
6612
HPRD ID
06972
03754
Ensembl ID
ENSG00000129521
ENSG00000184900
Uniprot IDs
B3KVT0
F8W1G2
Q3T1B0
Q9H6Z9
P55854
PDB IDs
1U4A
2IO1
2MP2
6K5R
6NNQ
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Difference)
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Tagcloud (Intersection)
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