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EGLN3 and SIAH2
Data Source:
BioGRID
(affinity chromatography technology, pull down, affinity chromatography technology)
EGLN3
SIAH2
Description
egl-9 family hypoxia inducible factor 3
siah E3 ubiquitin protein ligase 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleoplasm
Cytoplasm
Early Endosome
Cytosol
Neuron Projection
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Ferrous Iron Binding
2-oxoglutarate-dependent Dioxygenase Activity
L-ascorbic Acid Binding
Peptidyl-proline Dioxygenase Activity
Peptidyl-proline 4-dioxygenase Activity
Transcription Corepressor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Activity
Biological Process
Response To Hypoxia
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Protein Hydroxylation
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Regulation Of Cell Population Proliferation
Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Small GTPase Mediated Signal Transduction
Multicellular Organism Development
Protein Deubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Rhythmic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Netrin-activated Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Netrin-1 signaling
Ub-specific processing proteases
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Ascorbic acid
Roxadustat
Diseases
GWAS
Alzheimer's disease (late onset) (
30820047
)
Daytime sleep phenotypes (
27126917
)
Hematocrit (
32888494
27863252
)
Hemoglobin (
32888494
)
Red blood cell count (
32888494
)
BRCA1/2-negative high-risk breast cancer (
30323354
)
Breast cancer (
22951594
31757997
)
Interacting Genes
38 interacting genes:
ABI2
ADRB2
ATF4
CTBP2
DUSP7
EFHC2
EPAS1
EPOR
FAM168B
FOXJ2
GSC2
HIF1A
HIF3A
IK
IKBKG
IKZF3
LDB2
LNX1
MAPK1
MAPK7
MDM2
NCAPH2
NTAQ1
OS9
PKM
PLEKHA2
PRPF19
RBBP8NL
SERTAD1
SIAH2
SUMO1
SUMO2
SUMO3
TP53
TTC23L
WDR83
ZC2HC1A
ZNF655
43 interacting genes:
AFF1
AKR1C3
ATN1
CACYBP
CCBE1
CHEK2
DCC
DYRK2
EEF1D
EGLN3
HIPK2
HIPK3
MYD88
NRF1
OPRM1
PEG10
PEG3
PIAS2
PIAS3
PML
POU2AF1
PSMD4
RBBP8
SETD2
SNCA
SNCAIP
SPRY2
STAT3
SYP
TINF2
TP53BP2
TPX2
TRAF2
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2L6
UBE2N
UBE2V2
USP13
USP19
VAV1
Entrez ID
112399
6478
HPRD ID
06972
03737
Ensembl ID
ENSG00000129521
ENSG00000181788
Uniprot IDs
B3KVT0
F8W1G2
Q3T1B0
Q9H6Z9
O43255
PDB IDs
5H9M
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Intersection)
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