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EGLN3 and DUSP7
Data Source:
BioGRID
(two hybrid)
EGLN3
DUSP7
Description
egl-9 family hypoxia inducible factor 3
dual specificity phosphatase 7
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Ferrous Iron Binding
2-oxoglutarate-dependent Dioxygenase Activity
L-ascorbic Acid Binding
Peptidyl-proline Dioxygenase Activity
Peptidyl-proline 4-dioxygenase Activity
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/threonine Phosphatase Activity
MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
Mitogen-activated Protein Kinase Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Response To Hypoxia
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Protein Hydroxylation
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Regulation Of Cell Population Proliferation
Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
MAPK Cascade
Activation Of MAPK Activity
Inactivation Of MAPK Activity
Protein Dephosphorylation
Peptidyl-tyrosine Dephosphorylation
Peptidyl-threonine Dephosphorylation
Negative Regulation Of MAP Kinase Activity
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway
Signaling by MAPK mutants
Drugs
Ascorbic acid
Roxadustat
Diseases
GWAS
Alzheimer's disease (late onset) (
30820047
)
Daytime sleep phenotypes (
27126917
)
Hematocrit (
32888494
27863252
)
Hemoglobin (
32888494
)
Red blood cell count (
32888494
)
Interacting Genes
38 interacting genes:
ABI2
ADRB2
ATF4
CTBP2
DUSP7
EFHC2
EPAS1
EPOR
FAM168B
FOXJ2
GSC2
HIF1A
HIF3A
IK
IKBKG
IKZF3
LDB2
LNX1
MAPK1
MAPK7
MDM2
NCAPH2
NTAQ1
OS9
PKM
PLEKHA2
PRPF19
RBBP8NL
SERTAD1
SIAH2
SUMO1
SUMO2
SUMO3
TP53
TTC23L
WDR83
ZC2HC1A
ZNF655
7 interacting genes:
EEF1A1
EGLN3
GHR
IL16
MAPK1
MAPK14
MAPK8
Entrez ID
112399
1849
HPRD ID
06972
04125
Ensembl ID
ENSG00000129521
ENSG00000164086
Uniprot IDs
B3KVT0
F8W1G2
Q3T1B0
Q9H6Z9
Q16829
PDB IDs
4Y2E
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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