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EGLN3 and EFHC2
Data Source:
BioGRID
(two hybrid)
EGLN3
EFHC2
Description
egl-9 family hypoxia inducible factor 3
EF-hand domain containing 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule
Axoneme
Ciliary Basal Body
Mitotic Spindle
Molecular Function
Protein Binding
Ferrous Iron Binding
2-oxoglutarate-dependent Dioxygenase Activity
L-ascorbic Acid Binding
Peptidyl-proline Dioxygenase Activity
Peptidyl-proline 4-dioxygenase Activity
Calcium Ion Binding
Protein Binding
Alpha-tubulin Binding
Biological Process
Response To Hypoxia
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Protein Hydroxylation
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Regulation Of Cell Population Proliferation
Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Mitotic Cytokinesis
Mitotic Spindle Organization
Regulation Of Neuron Projection Development
Cilium-dependent Cell Motility
Cellular Response To Leukemia Inhibitory Factor
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Ascorbic acid
Roxadustat
Diseases
GWAS
Alzheimer's disease (late onset) (
30820047
)
Daytime sleep phenotypes (
27126917
)
Hematocrit (
32888494
27863252
)
Hemoglobin (
32888494
)
Red blood cell count (
32888494
)
Mean arterial pressure (
29403010
)
Interacting Genes
38 interacting genes:
ABI2
ADRB2
ATF4
CTBP2
DUSP7
EFHC2
EPAS1
EPOR
FAM168B
FOXJ2
GSC2
HIF1A
HIF3A
IK
IKBKG
IKZF3
LDB2
LNX1
MAPK1
MAPK7
MDM2
NCAPH2
NTAQ1
OS9
PKM
PLEKHA2
PRPF19
RBBP8NL
SERTAD1
SIAH2
SUMO1
SUMO2
SUMO3
TP53
TTC23L
WDR83
ZC2HC1A
ZNF655
100 interacting genes:
AASDHPPT
ARHGEF5
ARMC7
CABP2
CACNB4
CARD9
CCDC102B
CCDC120
CCDC13
CCDC57
CCHCR1
CCNG2
CDKN2A
CLIC3
COPE
CPNE2
CPNE7
CYFIP1
DCLK1
DDX6
DGCR6
DRC7
EDC3
EFHC1
EGLN3
EMD
ENKD1
ESRRG
EXOC8
EXOSC5
FAM107A
FAM124B
FAM214B
FAM221B
FBXL19
GEM
GLYCTK
GOLGA1
GPKOW
GRB2
GYS1
HDAC4
HGS
HNRNPLL
INPP5J
JAKMIP2
KANK2
KCTD7
KIF9
L3MBTL2
LMNB2
LMO2
LNX1
LONRF1
MAGOHB
MAPK9
MID2
MISP
MYLIP
MYO5B
NCDN
NCK2
NDOR1
NEK6
NFKBID
NME7
NR3C1
PBLD
PHF1
PIBF1
PICK1
PLOD3
POLR1C
PRPF18
PTK6
QARS1
RAD51D
RCOR3
RECK
RHOBTB3
RUNX1T1
SNRNP25
SOGA1
SPATA18
SPG21
STK16
TBC1D1
TBC1D22B
TEKT4
TRIM42
TRIM50
TSSK3
TUBGCP4
TXK
U2AF1
U2AF1L5
USP2
ZBTB16
ZFHX3
ZZZ3
Entrez ID
112399
80258
HPRD ID
06972
06540
Ensembl ID
ENSG00000129521
ENSG00000183690
Uniprot IDs
B3KVT0
F8W1G2
Q3T1B0
Q9H6Z9
Q5JST6
PDB IDs
2Z13
2Z14
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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