KATNA1 and DYRK2

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		KATNA1	DYRK2
Description		katanin catalytic subunit A1	dual specificity tyrosine phosphorylation regulated kinase 2
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Microtubule Cytoskeleton Midbody Mitotic Spindle Pole	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Ribonucleoprotein Complex
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Isomerase Activity ATPase Activity Protein Heterodimerization Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding
	Biological Process	Cell Cycle Cytoplasmic Microtubule Organization Microtubule Severing Cell Division	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Smoothened Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Lung cancer ( 27393504) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Malaria ( 31844061) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Systemic lupus erythematosus ( 28714469)
Interacting Genes		9 interacting genes: APP CLK1 CLU DCAF1 DYNC1H1 DYRK2 KATNB1 LIPE PAFAH1B1	22 interacting genes: APP ATM DYRK4 EIF2B5 H2BC21 H3-4 IKZF1 KATNA1 KXD1 LRRK2 LZTS2 MAPT MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBE2D1 UBR5 WDR62 ZBTB9
Entrez ID		11104	8445
HPRD ID		05986	04606
Ensembl ID		ENSG00000186625	ENSG00000127334
Uniprot IDs		A8K7S5 O75449	Q92630
PDB IDs		5ZQL 5ZQM	3K2L 3KVW 4AZF 5LXC 5LXD 5ZTN 6HDP 6HDR 6K0J
Enriched GO Terms of Interacting Partners?
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