KATNA1 and KATNB1

Data Source:
HPRD (in vivo, in vitro)

		KATNA1	KATNB1
Description		katanin catalytic subunit A1	katanin regulatory subunit B1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Microtubule Cytoskeleton Midbody Mitotic Spindle Pole	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Cytosol Microtubule Plasma Membrane Katanin Complex Microtubule Cytoskeleton Membrane Growth Cone Midbody Neuronal Cell Body
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Isomerase Activity ATPase Activity Protein Heterodimerization Activity	Protein Binding Microtubule Binding Protein Heterodimerization Activity ATPase Regulator Activity Dynein Complex Binding
	Biological Process	Cell Cycle Cytoplasmic Microtubule Organization Microtubule Severing Cell Division	Protein Targeting Microtubule Depolymerization Negative Regulation Of Microtubule Depolymerization Mitotic Chromosome Movement Towards Spindle Pole Positive Regulation Of Cell Death Positive Regulation Of Neuron Projection Development Positive Regulation Of Microtubule Depolymerization Regulation Of Catalytic Activity Microtubule Severing Cell Division
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Lung cancer ( 27393504) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)
Interacting Genes		9 interacting genes: APP CLK1 CLU DCAF1 DYNC1H1 DYRK2 KATNB1 LIPE PAFAH1B1	6 interacting genes: DYNC1H1 KATNA1 PAFAH1B1 RXFP3 TGFBR1 XRN1
Entrez ID		11104	10300
HPRD ID		05986	04081
Ensembl ID		ENSG00000186625	ENSG00000140854
Uniprot IDs		A8K7S5 O75449	Q9BVA0
PDB IDs		5ZQL 5ZQM
Enriched GO Terms of Interacting Partners?
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