DYRK2 and DYRK4

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		DYRK2	DYRK4
Description		dual specificity tyrosine phosphorylation regulated kinase 2	dual specificity tyrosine phosphorylation regulated kinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Ribonucleoprotein Complex	Nucleus Cytoplasm Cytoskeleton Intracellular Membrane-bounded Organelle
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Smoothened Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction By P53 Class Mediator	Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation
Pathways		Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Malaria ( 31844061) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Systemic lupus erythematosus ( 28714469)	Allergic rhinitis ( 25085501)
Interacting Genes		22 interacting genes: APP ATM DYRK4 EIF2B5 H2BC21 H3-4 IKZF1 KATNA1 KXD1 LRRK2 LZTS2 MAPT MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBE2D1 UBR5 WDR62 ZBTB9	6 interacting genes: CUL3 DYRK2 FBXO25 MID1 NEDD4 PPP1CC
Entrez ID		8445	8798
HPRD ID		04606	10926
Ensembl ID		ENSG00000127334	ENSG00000010219
Uniprot IDs		Q92630	B4E1A4 D3JEN2 Q9NR20
PDB IDs		3K2L 3KVW 4AZF 5LXC 5LXD 5ZTN 6HDP 6HDR 6K0J
Enriched GO Terms of Interacting Partners?
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