KATNA1 and DCAF1

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)

		KATNA1	DCAF1
Description		katanin catalytic subunit A1	DDB1 and CUL4 associated factor 1
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Microtubule Cytoskeleton Midbody Mitotic Spindle Pole	Fibrillar Center Nucleus Nucleoplasm Cytoplasm COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Isomerase Activity ATPase Activity Protein Heterodimerization Activity	Protein Binding ATP Binding Estrogen Receptor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Histone Kinase Activity (H2A-T120 Specific)
	Biological Process	Cell Cycle Cytoplasmic Microtubule Organization Microtubule Severing Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Lung cancer ( 27393504) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Asthma ( 32296059)
Interacting Genes		9 interacting genes: APP CLK1 CLU DCAF1 DYNC1H1 DYRK2 KATNB1 LIPE PAFAH1B1	19 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF KATNA1 NF2 PRKDC PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2
Entrez ID		11104	9730
HPRD ID		05986	11674
Ensembl ID		ENSG00000186625	ENSG00000145041
Uniprot IDs		A8K7S5 O75449	Q9Y4B6
PDB IDs		5ZQL 5ZQM	3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45
Enriched GO Terms of Interacting Partners?
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