KATNA1 and PAFAH1B1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		KATNA1	PAFAH1B1
Description		katanin catalytic subunit A1	platelet activating factor acetylhydrolase 1b regulatory subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Microtubule Cytoskeleton Midbody Mitotic Spindle Pole	Astral Microtubule Kinetochore Nuclear Envelope Centrosome Cytosol Microtubule Associated Complex Cytoplasmic Microtubule Cell Cortex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Cell Leading Edge Motile Cilium Nuclear Membrane Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Axon Cytoplasm
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Isomerase Activity ATPase Activity Protein Heterodimerization Activity	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Identical Protein Binding Phospholipase Binding Protein Heterodimerization Activity Microtubule Plus-end Binding Phosphoprotein Binding Dynein Complex Binding
	Biological Process	Cell Cycle Cytoplasmic Microtubule Organization Microtubule Severing Cell Division	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Acrosome Assembly Neuron Migration Microtubule-based Process Nuclear Migration Chemical Synaptic Transmission Germ Cell Development Neuroblast Proliferation Learning Or Memory Retrograde Axonal Transport Adult Locomotory Behavior Regulation Of G2/M Transition Of Mitotic Cell Cycle Lipid Catabolic Process Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Development Actin Cytoskeleton Organization Microtubule Organizing Center Organization Reelin-mediated Signaling Pathway Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Neuromuscular Process Controlling Balance Microtubule Sliding Cell Division Ciliary Basal Body-plasma Membrane Docking Regulation Of Microtubule Motor Activity
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Brain morphology (MOSTest) ( 32665545) Lung cancer ( 27393504) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Adverse response to drug ( 30420678) Mean platelet volume ( 32888494) Neurociticism ( 29500382) Neuroticism ( 27089181) Self-reported tiredness ( 28194004)
Interacting Genes		9 interacting genes: APP CLK1 CLU DCAF1 DYNC1H1 DYRK2 KATNB1 LIPE PAFAH1B1	22 interacting genes: CLIP1 CSNK2A1 DAB1 DCTN1 DCTN2 DCX DNAI1 FBXO7 HSPH1 KARS1 KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D TNIK TUBA1A
Entrez ID		11104	5048
HPRD ID		05986	03329
Ensembl ID		ENSG00000186625	ENSG00000007168
Uniprot IDs		A8K7S5 O75449	A0A6Q8PFT2 A0A6Q8PFU3 P43034
PDB IDs		5ZQL 5ZQM
Enriched GO Terms of Interacting Partners?
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