DYRK2 and KXD1

Data Source:
BioGRID (two hybrid)

		DYRK2	KXD1
Description		dual specificity tyrosine phosphorylation regulated kinase 2	KxDL motif containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Ribonucleoprotein Complex	Lysosomal Membrane BLOC-1 Complex BORC Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding	Protein Binding
	Biological Process	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Smoothened Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction By P53 Class Mediator	Vesicle-mediated Transport Lysosome Localization
Pathways		Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Malaria ( 31844061) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Systemic lupus erythematosus ( 28714469)
Interacting Genes		22 interacting genes: APP ATM DYRK4 EIF2B5 H2BC21 H3-4 IKZF1 KATNA1 KXD1 LRRK2 LZTS2 MAPT MDM2 NR1I2 RAD54B SIAH2 SP100 TERT UBE2D1 UBR5 WDR62 ZBTB9	44 interacting genes: APPL1 ARHGDIG BORCS6 C4orf46 CCDC185 CCDC33 CEP170P1 CEP19 CEP63 DYRK2 ELOA ELOA2 EWSR1 EXOC5 EXOC7 FXR2 GABARAPL1 HAUS1 IFT20 ING5 ITSN2 KRT81 LMO3 LNX1 LRRC45 MAB21L3 MAP1LC3A MAP1LC3B MCRS1 MOB1A MYH7 NIF3L1 NUDT18 RABGEF1 RNF183 RPL9 STX11 TCEA2 TPM1 TPM3 UTP6 ZBTB25 ZC4H2 ZNF417
Entrez ID		8445	79036
HPRD ID		04606	14526
Ensembl ID		ENSG00000127334	ENSG00000105700
Uniprot IDs		Q92630	A0A024R7M2 Q9BQD3
PDB IDs		3K2L 3KVW 4AZF 5LXC 5LXD 5ZTN 6HDP 6HDR 6K0J
Enriched GO Terms of Interacting Partners?
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