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SEC23A and DCTN1
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
SEC23A
DCTN1
Description
SEC23 homolog A, COPII coat complex component
dynactin subunit 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
Extrinsic Component Of Membrane
COPII Vesicle Coat
Perinuclear Region Of Cytoplasm
Endoplasmic Reticulum Exit Site
Kinetochore
Spindle Pole
Nucleus
Nuclear Envelope
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Microtubule
Microtubule Associated Complex
Cell Cortex
Microtubule Cytoskeleton
Membrane
Dynein Complex
Axon
Retromer Complex
Microtubule Plus-end
Neuron Projection
Neuronal Cell Body
Intercellular Bridge
Mitotic Spindle
Cell Cortex Region
Centriolar Subdistal Appendage
Molecular Function
GTPase Activator Activity
Protein Binding
Zinc Ion Binding
Motor Activity
Protein Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Tau Protein Binding
Microtubule Plus-end Binding
Biological Process
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Intracellular Protein Transport
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Positive Regulation Of GTPase Activity
COPII Vesicle Coating
Protein Localization To Plasma Membrane
COPII-coated Vesicle Cargo Loading
G2/M Transition Of Mitotic Cell Cycle
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Nuclear Migration
Nervous System Development
Neuromuscular Junction Development
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Centriole-centriole Cohesion
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Ventral Spinal Cord Development
Positive Regulation Of Microtubule Polymerization
Cytoplasmic Microtubule Organization
Microtubule Anchoring At Centrosome
IRE1-mediated Unfolded Protein Response
Retrograde Transport, Endosome To Golgi
Neuromuscular Process
Nuclear Envelope Disassembly
Cell Division
Regulation Of Mitotic Spindle Organization
Motor Behavior
Neuron Cellular Homeostasis
Positive Regulation Of Microtubule Nucleation
Ciliary Basal Body-plasma Membrane Docking
Axonal Transport
Maintenance Of Synapse Structure
Positive Regulation Of Neuromuscular Junction Development
Non-motile Cilium Assembly
Neuron Projection Maintenance
Pathways
Regulation of cholesterol biosynthesis by SREBP (SREBF)
COPII-mediated vesicle transport
MHC class II antigen presentation
Cargo concentration in the ER
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
XBP1(S) activates chaperone genes
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
Cranio-lenticulo-sutural dysplasia (CLSD); Boyadjiev-Jabs syndrome
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Perry syndrome
Distal hereditary motor neuropathies (dHMN)
GWAS
Metabolite levels (
23823483
)
Vitamin D levels (
29343764
)
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Refractive error (
32231278
)
Interacting Genes
35 interacting genes:
BNIP3
CADPS
CDK16
CDK18
CLEC17A
DCTN1
DNM2
DTX2
ERGIC3
ERLIN1
FASLG
FATE1
GJA8
GLRA2
HOMEZ
MFF
MIA2
MIA3
MINAR1
NDRG1
PIAS2
RNF19B
SDCBP2
SEC16A
SEC23B
SEC23IP
SEC24B
SEC24C
SEC24D
SF1
SLC7A1
SUCLA2
TMEM45B
TNFSF14
WBP11
46 interacting genes:
ACTR1A
ACTR1B
AKT1
APEX1
BBS1
BBS4
BICD1
BICD2
CASP2
CASP3
CASP7
CDC37
CLIP1
DCTN3
DISC1
DST
DTNBP1
DYNC1I2
ENO3
FBXL5
GRB2
GSK3B
HAP1
HSPB2
KIAA0408
KIF11
MAP2K3
MAP2K6
MAPRE1
MED14
MTERF1
NEK2
NOD2
PAFAH1B1
PFDN1
PGAM1
PPP1CA
RAB6A
RBL2
RPGR
SEC23A
SPTBN2
STAT1
TP53RK
VIM
ZNF512B
Entrez ID
10484
1639
HPRD ID
06714
07206
Ensembl ID
ENSG00000100934
ENSG00000204843
Uniprot IDs
Q15436
Q14203
Q6MZZ3
PDB IDs
2NUP
2NUT
2YRC
2YRD
3EFO
3EG9
3EGD
3EGX
5KYN
5KYU
5KYW
5KYX
5KYY
5VNE
5VNF
5VNG
5VNH
5VNI
5VNJ
5VNK
5VNL
5VNM
5VNN
5VNO
1TXQ
2COY
2HKN
2HKQ
2HL3
2HL5
2HQH
3E2U
3TQ7
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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