SEC23A and SEC23IP

Data Source:
BioGRID (two hybrid)

		SEC23A	SEC23IP
Description		SEC23 homolog A, COPII coat complex component	SEC23 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Extrinsic Component Of Membrane COPII Vesicle Coat Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane COPII-coated ER To Golgi Transport Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding	RNA Binding Phospholipase Activity Protein Binding Metal Ion Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of GTPase Activity COPII Vesicle Coating Protein Localization To Plasma Membrane COPII-coated Vesicle Cargo Loading	Intracellular Protein Transport Golgi Organization COPII Vesicle Coating
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Antigen Presentation: Folding, assembly and peptide loading of class I MHC	COPII-mediated vesicle transport
Drugs
Diseases		Cranio-lenticulo-sutural dysplasia (CLSD); Boyadjiev-Jabs syndrome
GWAS		Metabolite levels ( 23823483) Vitamin D levels ( 29343764)	Cerebrospinal fluid clusterin levels ( 26545630) HDL cholesterol levels ( 32203549) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870)
Interacting Genes		35 interacting genes: BNIP3 CADPS CDK16 CDK18 CLEC17A DCTN1 DNM2 DTX2 ERGIC3 ERLIN1 FASLG FATE1 GJA8 GLRA2 HOMEZ MFF MIA2 MIA3 MINAR1 NDRG1 PIAS2 RNF19B SDCBP2 SEC16A SEC23B SEC23IP SEC24B SEC24C SEC24D SF1 SLC7A1 SUCLA2 TMEM45B TNFSF14 WBP11	7 interacting genes: HSPB11 PCNA POLD4 SEC23A SSC5D WWOX YIF1A
Entrez ID		10484	11196
HPRD ID		06714	07152
Ensembl ID		ENSG00000100934	ENSG00000107651
Uniprot IDs		Q15436	Q9Y6Y8
PDB IDs		2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX 5KYN 5KYU 5KYW 5KYX 5KYY 5VNE 5VNF 5VNG 5VNH 5VNI 5VNJ 5VNK 5VNL 5VNM 5VNN 5VNO
Enriched GO Terms of Interacting Partners?
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