DCTN1 and FBXL5

Data Source:
BioGRID (pull down)

		DCTN1	FBXL5
Description		dynactin subunit 1	F-box and leucine rich repeat protein 5
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GO Annotations	Cellular Component	Kinetochore Spindle Pole Nucleus Nuclear Envelope Cytoplasm Centrosome Centriole Spindle Cytosol Microtubule Microtubule Associated Complex Cell Cortex Microtubule Cytoskeleton Membrane Dynein Complex Axon Retromer Complex Microtubule Plus-end Neuron Projection Neuronal Cell Body Intercellular Bridge Mitotic Spindle Cell Cortex Region Centriolar Subdistal Appendage	Ubiquitin Ligase Complex Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Motor Activity Protein Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Tau Protein Binding Microtubule Plus-end Binding	Ubiquitin-protein Transferase Activity Iron Ion Binding Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Nuclear Migration Nervous System Development Neuromuscular Junction Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ventral Spinal Cord Development Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome IRE1-mediated Unfolded Protein Response Retrograde Transport, Endosome To Golgi Neuromuscular Process Nuclear Envelope Disassembly Cell Division Regulation Of Mitotic Spindle Organization Motor Behavior Neuron Cellular Homeostasis Positive Regulation Of Microtubule Nucleation Ciliary Basal Body-plasma Membrane Docking Axonal Transport Maintenance Of Synapse Structure Positive Regulation Of Neuromuscular Junction Development Non-motile Cilium Assembly Neuron Projection Maintenance	Protein Polyubiquitination Cellular Iron Ion Homeostasis Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Iron Ion Homeostasis Positive Regulation Of Cellular Protein Catabolic Process
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic	Association of TriC/CCT with target proteins during biosynthesis Neddylation Iron uptake and transport Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Perry syndrome Distal hereditary motor neuropathies (dHMN)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Refractive error ( 32231278)	Blood protein levels ( 28240269) Estimated glomerular filtration rate in non-diabetics ( 31451708) Red blood cell count ( 32888494)
Interacting Genes		46 interacting genes: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 ENO3 FBXL5 GRB2 GSK3B HAP1 HSPB2 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 NOD2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 TP53RK VIM ZNF512B	11 interacting genes: CITED2 CSNK2B DCTN1 EP300 IREB2 LINC00839 NABP2 ORC4 PLK1 SKP1 SNCA
Entrez ID		1639	26234
HPRD ID		07206	05739
Ensembl ID		ENSG00000204843	ENSG00000118564
Uniprot IDs		Q14203 Q6MZZ3	Q9UKA1
PDB IDs		1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7	3U9J 3U9M 3V5X 3V5Y 3V5Z 6VCD
Enriched GO Terms of Interacting Partners?
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