FAM3C and CYB5R3

Data Source:
BioGRID (two hybrid)

		FAM3C	CYB5R3
Description		FAM3 metabolism regulating signaling molecule C	cytochrome b5 reductase 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Platelet Dense Granule Lumen Extracellular Exosome	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex
	Molecular Function	Cytokine Activity Protein Binding	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding Nitrite Reductase (NO-forming) Activity NAD Binding FAD Binding
	Biological Process	Platelet Degranulation Signal Transduction Multicellular Organism Development Biological_process Negative Regulation Of Gluconeogenesis	Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Blood Circulation L-ascorbic Acid Metabolic Process Neutrophil Degranulation
Pathways		Platelet degranulation	Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs			NADH Flavin adenine dinucleotide Copper
Diseases			Methemoglobinemia
GWAS		Biomedical quantitative traits ( 19396169) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Calcaneus stiffness index ( 30779856) Forearm bone mineral density ( 26367794) Hand grip strength ( 27325353) Heel bone mineral density ( 30598549 28869591) Lung adenocarcinoma ( 28604730) Pediatric bone mineral content (radius) ( 26041818) Phenylephrine infusion rate during anesthesia ( 31455332) Total body bone mineral density ( 30172743) Ulna and radius bone mineral density ( 30172743)	Initial pursuit acceleration ( 29064472)
Interacting Genes		48 interacting genes: AHNAK2 BIK BNIP2 CLEC17A CLEC2D CLEC4E CREB3 CREB3L1 CXADR CYB5R3 ELOVL4 ERGIC3 EVI2B FAM209A FCGR1A FCGRT FFAR2 FKBP7 GGT6 GJB5 GPR42 GPX8 HHLA2 KCNA2 KIR2DL3 LMNA LRRC25 MFF PDZK1IP1 RELL2 RMDN3 RNASEH1 SAR1A SCN3B SLC10A6 SLC16A2 SLC18A1 SLC35C2 SPINT1 SSMEM1 STX1A TEX29 TMEM248 TMEM45B TMEM71 TMEM80 TMPRSS2 TMX2	61 interacting genes: ADAM33 AGTRAP AIG1 ALG8 AQP6 ASGR1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PNLIPRP1 REEP4 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 ZDHHC15
Entrez ID		10447	1727
HPRD ID		12270	08942
Ensembl ID		ENSG00000196937	ENSG00000100243
Uniprot IDs		Q92520	P00387
PDB IDs		5LC2	1M91 1UMK
Enriched GO Terms of Interacting Partners?
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