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CYB5R3 and TNF
Data Source:
BioGRID
(two hybrid)
CYB5R3
TNF
Description
cytochrome b5 reductase 3
tumor necrosis factor
Image
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Lipid Droplet
Hemoglobin Complex
Membrane
Azurophil Granule Lumen
Nitric-oxide Synthase Complex
Phagocytic Cup
Extracellular Region
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane Raft
Recycling Endosome
Molecular Function
Cytochrome-b5 Reductase Activity, Acting On NAD(P)H
Protein Binding
AMP Binding
ADP Binding
Nitrite Reductase (NO-forming) Activity
NAD Binding
FAD Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Protease Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Identical Protein Binding
Biological Process
Cholesterol Biosynthetic Process
Xenobiotic Metabolic Process
Nitric Oxide Biosynthetic Process
Blood Circulation
L-ascorbic Acid Metabolic Process
Neutrophil Degranulation
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Activation Of MAPKKK Activity
Activation Of MAPK Activity
Microglial Cell Activation
Positive Regulation Of Cytokine Production
Positive Regulation Of Protein Phosphorylation
Negative Regulation Of Endothelial Cell Proliferation
Chronic Inflammatory Response To Antigenic Stimulus
Regulation Of Immunoglobulin Production
Negative Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Glucose Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Response
Humoral Immune Response
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Virus
Response To Salt Stress
Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Alkaline Phosphatase Activity
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Lipid Storage
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cytokine-mediated Signaling Pathway
Extracellular Matrix Organization
Osteoclast Differentiation
Sequestering Of Triglyceride
Cortical Actin Cytoskeleton Organization
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Fever Generation
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Interleukin-6 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Fractalkine Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Heterotypic Cell-cell Adhesion
Negative Regulation Of Myosin-light-chain-phosphatase Activity
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Protein-containing Complex Disassembly
Positive Regulation Of Protein-containing Complex Disassembly
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Protein Kinase B Signaling
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Fat Cell Differentiation
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Cell Adhesion
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Translational Initiation By Iron
Negative Regulation Of Glucose Import
Positive Regulation Of JNK Cascade
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Astrocyte Activation
Embryonic Digestive Tract Development
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Inflammatory Response
Positive Regulation Of Phagocytosis
Negative Regulation Of Neurogenesis
Regulation Of Insulin Secretion
Positive Regulation Of Synaptic Transmission
Regulation Of Synapse Organization
Defense Response To Gram-positive Bacterium
Cognition
Leukocyte Tethering Or Rolling
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Protein Transport
Response To Glucocorticoid
Positive Regulation Of Hair Follicle Development
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Synaptic Transmission, Glutamatergic
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Vitamin D Biosynthetic Process
Positive Regulation Of Calcidiol 1-monooxygenase Activity
Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
Regulation Of Branching Involved In Salivary Gland Morphogenesis
Negative Regulation Of Vascular Wound Healing
Negative Regulation Of Branching Involved In Lung Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Amino Acid Stimulus
Cellular Response To Nicotine
Cellular Response To Organic Cyclic Compound
Death-inducing Signaling Complex Assembly
Positive Regulation Of Mononuclear Cell Migration
Positive Regulation Of Podosome Assembly
Endothelial Cell Apoptotic Process
Protein Localization To Plasma Membrane
Extrinsic Apoptotic Signaling Pathway
Necroptotic Signaling Pathway
Positive Regulation Of Neuroinflammatory Response
Positive Regulation Of Interleukin-33 Production
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Amyloid-beta Clearance
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Synoviocyte Proliferation
Positive Regulation Of Superoxide Dismutase Activity
Positive Regulation Of Amyloid-beta Formation
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Protein Localization To Plasma Membrane
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Positive Regulation Of I-kappaB Phosphorylation
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Positive Regulation Of Protein Localization To Cell Surface
Negative Regulation Of Signaling Receptor Activity
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Blood Microparticle Formation
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Vitamin C (ascorbate) metabolism
Phase I - Functionalization of compounds
Neutrophil degranulation
Transcriptional regulation of white adipocyte differentiation
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFR2 non-canonical NF-kB pathway
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
TNF signaling
Drugs
NADH
Flavin adenine dinucleotide
Copper
Etanercept
Adalimumab
Infliximab
Chloroquine
Epinephrine
Pseudoephedrine
Thalidomide
Glucosamine
Clenbuterol
Pranlukast
Amrinone
Afelimomab
YSIL6
SD118
PN0621
OMS-103HP
Talmapimod
VX-702
Atiprimod
CRx-139
CYT007-TNFQb
Andrographolide
Ethyl pyruvate
AME-527
PR-104
Plinabulin
Dexanabinol
Onercept
Golimumab
Certolizumab pegol
Pomalidomide
Polaprezinc
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Bryostatin 1
Binimetinib
Dilmapimod
Glycyrrhizic acid
Diseases
Methemoglobinemia
Graft-versus-host disease
Asthma
Allograft rejection
Systemic lupus erythematosus
GWAS
Initial pursuit acceleration (
29064472
)
AIDS progression (
19115949
)
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Cervical cancer (
28806749
)
Crohn's disease (
21102463
)
Inflammatory bowel disease (
28067908
)
Malaria (
31844061
)
Neonatal lupus (
20662065
)
Psychosis (atypical) (
24132900
)
Pulse pressure (
30578418
)
Ulcerative colitis (
28067908
)
Interacting Genes
61 interacting genes:
ADAM33
AGTRAP
AIG1
ALG8
AQP6
ASGR1
BNIP2
CDIPT
CERS4
CNIH1
COL8A2
CSGALNACT2
CYB5A
CYCS
ELOVL4
FAM210B
FAM3C
FAXDC2
FUNDC2
FXYD3
GAST
GPR152
GRM2
HBG2
HSD17B13
LAPTM5
LRCH4
MFSD6
NINJ1
NRM
NSG1
NXPE3
ORMDL2
PNLIPRP1
REEP4
SLC10A1
SLC10A6
SLC13A3
SLC22A2
SLC35A4
SLC35B2
SLC38A7
SPP1
STOM
TMEM115
TMEM14B
TMEM14C
TMEM201
TMEM31
TMEM51
TMEM60
TMEM79
TNF
TNFRSF10C
UBIAD1
VAMP1
VAMP4
VAMP5
VMP1
WFDC2
ZDHHC15
53 interacting genes:
ADAM17
ADAM9
AQP3
BCL2L13
BGN
BTNL9
C10orf67
CCDC107
CCDC70
CLDN7
CLEC10A
CREB3L1
CSF1
CYB5R3
DCN
FAM209A
FFAR2
FNDC9
FYN
IFNG
KASH5
LMNA
LRRC25
LRRTM2
LYN
MMP17
MRM3
NFKBIA
PAGE1
PANX1
PDIK1L
PIP4P2
PLEKHO1
POU2F1
PRTN3
RC3H1
RIPK1
RNF19B
SEC61A1
SGCB
SLC14A2
SLC30A4
SSMEM1
STOM
STX1A
TMPRSS2
TNFRSF1A
TNFRSF1B
TRAF2
VSIR
YWHAQ
ZCCHC12
ZFP36
Entrez ID
1727
7124
HPRD ID
08942
01855
Ensembl ID
ENSG00000100243
ENSG00000232810
Uniprot IDs
P00387
P01375
Q5STB3
PDB IDs
1M91
1UMK
1A8M
1TNF
2AZ5
2E7A
2TUN
2ZJC
2ZPX
3ALQ
3IT8
3L9J
3WD5
4G3Y
4TSV
4TWT
4Y6O
5M2I
5M2J
5M2M
5MU8
5TSW
5UUI
5WUX
5YOY
6OOY
6OOZ
6OP0
6RMJ
Enriched GO Terms of Interacting Partners
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