Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
CYB5R3 and CYCS
Data Source:
HPRD
(in vitro)
CYB5R3
CYCS
Description
cytochrome b5 reductase 3
cytochrome c, somatic
Image
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Lipid Droplet
Hemoglobin Complex
Membrane
Azurophil Granule Lumen
Nitric-oxide Synthase Complex
Protein Phosphatase Type 2A Complex
Nucleus
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Cytosol
Respirasome
Molecular Function
Cytochrome-b5 Reductase Activity, Acting On NAD(P)H
Protein Binding
AMP Binding
ADP Binding
Nitrite Reductase (NO-forming) Activity
NAD Binding
FAD Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Heme Binding
Metal Ion Binding
Biological Process
Cholesterol Biosynthetic Process
Xenobiotic Metabolic Process
Nitric Oxide Biosynthetic Process
Blood Circulation
L-ascorbic Acid Metabolic Process
Neutrophil Degranulation
Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
Mitochondrial Electron Transport, Cytochrome C To Oxygen
Protein Dephosphorylation
Apoptotic Process
Mitochondrion Organization
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Cellular Response To Oxidative Stress
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Respiration
Pathways
Vitamin C (ascorbate) metabolism
Phase I - Functionalization of compounds
Neutrophil degranulation
Release of apoptotic factors from the mitochondria
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Transcriptional activation of mitochondrial biogenesis
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
Respiratory electron transport
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Drugs
NADH
Flavin adenine dinucleotide
Copper
Minocycline
Protoporphyrin Ix Containing Co
Ferroheme C
Imidazole
Zinc protoporphyrin
Trimethyllysine
Zinc Substituted Heme C
Artenimol
Diseases
Methemoglobinemia
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS
Initial pursuit acceleration (
29064472
)
Alzheimer's disease (cognitive decline) (
23535033
)
High density lipoprotein cholesterol levels (
30498476
)
Systemic lupus erythematosus (
19838195
)
Interacting Genes
61 interacting genes:
ADAM33
AGTRAP
AIG1
ALG8
AQP6
ASGR1
BNIP2
CDIPT
CERS4
CNIH1
COL8A2
CSGALNACT2
CYB5A
CYCS
ELOVL4
FAM210B
FAM3C
FAXDC2
FUNDC2
FXYD3
GAST
GPR152
GRM2
HBG2
HSD17B13
LAPTM5
LRCH4
MFSD6
NINJ1
NRM
NSG1
NXPE3
ORMDL2
PNLIPRP1
REEP4
SLC10A1
SLC10A6
SLC13A3
SLC22A2
SLC35A4
SLC35B2
SLC38A7
SPP1
STOM
TMEM115
TMEM14B
TMEM14C
TMEM201
TMEM31
TMEM51
TMEM60
TMEM79
TNF
TNFRSF10C
UBIAD1
VAMP1
VAMP4
VAMP5
VMP1
WFDC2
ZDHHC15
22 interacting genes:
AGTPBP1
APAF1
BCL2
BCL2L1
CASP9
COX4I2
CUL9
CYB5A
CYB5R1
CYB5R3
CYC1
FDX1
HSPA8
HSPB1
KRT40
MEOX2
NDOR1
RNF7
SAFB
SNCA
UQCRC1
VDAC2
Entrez ID
1727
54205
HPRD ID
08942
00479
Ensembl ID
ENSG00000100243
ENSG00000172115
Uniprot IDs
P00387
G4XXL9
P99999
PDB IDs
1M91
1UMK
1J3S
2N3Y
2N9I
2N9J
3NWV
3ZCF
3ZOO
5EXQ
5O10
5TY3
6DUJ
6ECJ
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?