SPRY3 and NEK6

Data Source:
BioGRID (two hybrid)

		SPRY3	NEK6
Description		sprouty RTK signaling antagonist 3	NIMA related kinase 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite
	Molecular Function	Molecular_function Protein Binding	Magnesium Ion Binding Transcription Corepressor Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Multicellular Organism Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Axon Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neuron Projection Arborization	Protein Phosphorylation Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence
Pathways			Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Idiopathic osteonecrosis of the femoral head ( 28000841) Iron status biomarkers (transferrin saturation) ( 28334935)	Asthma ( 32296059) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Vitiligo ( 27723757)
Interacting Genes		27 interacting genes: AQP1 BEX2 CATSPER1 CHRD CREB5 GNE GPSM3 HOXA1 HR KPRP KRT34 LCE1A LCE1B LCE1F LCE2B LCE3A LCE3D LCE3E MAPKBP1 MEOX2 NEK6 R3HDM2 SLC39A7 VSNL1 ZDHHC17 ZNF587 ZNF655	117 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 BEND7 BHLHE40 CBY2 CCDC120 CCDC136 CCDC85B CDC42 CDK7 CEP76 CFP CIR1 COG6 CTBP2 DDIT4L DES DPH2 EFHC2 ERCC6L2 FAM220A FHL5 FOXJ3 GFAP GIGYF1 GLIS3 GOLGA6L2 GRIP1 HOMEZ HOOK2 HOXA1 HOXB6 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KATNBL1 KCTD5 KIAA1328 KRT31 KRT34 KRT40 KRT75 KRT8 KRTAP10-8 KRTAP13-1 KRTAP13-3 LNX1 LZTS1 LZTS2 MBD3L1 MEOX2 METTL15 MYOG MYOZ3 NECAB2 NEFL NEK9 NIF3L1 NUDT16L1 PAK6 PBX4 PHF1 PICK1 PIN1 PLEKHA7 PPP1R16A PRAM1 PRDM16 PRDM6 PRDX3 PRICKLE4 PTN PTPN21 PTPRD RBAK RBBP6 RIMBP3C RPS6KB1 RPS7 SAXO1 SGK1 SH3RF2 SMAD4 SMUG1 SMURF2 SORBS3 SPRY3 TASOR2 TCF12 TCF4 TEPSIN TEX45 TFIP11 TGFBR1 TLE5 TNK2 TRAF2 TRIM23 TRIM27 TRIM54 TRIP4 UBXN11 XIAP ZC2HC1C ZCCHC7 ZFP90 ZNF24 ZNF343 ZNF438 ZNF587 ZNF688 ZNF774 ZRANB1
Entrez ID		10251	10783
HPRD ID		03917	05348
Ensembl ID		ENSG00000168939	ENSG00000119408
Uniprot IDs		O43610 Q6ZUP3	A0A024R8A6 Q9HC98
PDB IDs
Enriched GO Terms of Interacting Partners?
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