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NEK6 and HOXA1
Data Source:
BioGRID
(two hybrid)
NEK6
HOXA1
Description
NIMA related kinase 6
homeobox A1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Microtubule
Nuclear Speck
Protein-containing Complex
Centriolar Satellite
Chromatin
Nucleus
Molecular Function
Magnesium Ion Binding
Transcription Corepressor Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinesin Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Activating Transcription Factor Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Identical Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Protein Phosphorylation
Apoptotic Process
Chromosome Segregation
Mitotic Nuclear Envelope Disassembly
Regulation Of Mitotic Cell Cycle
Peptidyl-serine Phosphorylation
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Protein Autophosphorylation
Spindle Assembly
Cell Division
Regulation Of Cellular Senescence
Regulation Of Transcription By RNA Polymerase II
Multicellular Organism Development
Sensory Perception Of Sound
Optokinetic Behavior
Anatomical Structure Morphogenesis
Abducens Nerve Formation
Outer Ear Morphogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Neurocranium Morphogenesis
Inner Ear Development
Artery Morphogenesis
Regulation Of Behavior
Cognition
Neuromuscular Process
Artery Development
Semicircular Canal Formation
Cochlea Development
Cochlea Morphogenesis
Pathways
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
EML4 and NUDC in mitotic spindle formation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome
GWAS
Asthma (
32296059
)
Asthma exacerbations in inhaled corticosteroid treatment (
30697902
)
Blond vs. brown/black hair color (
30531825
)
Chronotype (
30696823
)
Cognitive performance (
20125193
)
Free thyroxine concentration (
30367059
)
Heel bone mineral density (
30598549
)
Medication use (thyroid preparations) (
31015401
)
Mercury levels (
26025379
)
Neurociticism (
29500382
)
Pulse pressure (
30224653
)
Thyroid stimulating hormone levels (
32769997
)
Vitiligo (
27723757
)
Chronic venous disease (
28374850
)
Macular thickness (
30535121
)
Multiple sclerosis (
31604244
)
Small cell lung carcinoma (
28604730
)
Tonsillectomy (
27182965
28928442
)
Interacting Genes
117 interacting genes:
ANKRA2
ARHGAP33
ARRB1
ATF4
BEND7
BHLHE40
CBY2
CCDC120
CCDC136
CCDC85B
CDC42
CDK7
CEP76
CFP
CIR1
COG6
CTBP2
DDIT4L
DES
DPH2
EFHC2
ERCC6L2
FAM220A
FHL5
FOXJ3
GFAP
GIGYF1
GLIS3
GOLGA6L2
GRIP1
HOMEZ
HOOK2
HOXA1
HOXB6
HSD17B14
IHO1
IKZF1
IKZF3
INCA1
KATNBL1
KCTD5
KIAA1328
KRT31
KRT34
KRT40
KRT75
KRT8
KRTAP10-8
KRTAP13-1
KRTAP13-3
LNX1
LZTS1
LZTS2
MBD3L1
MEOX2
METTL15
MYOG
MYOZ3
NECAB2
NEFL
NEK9
NIF3L1
NUDT16L1
PAK6
PBX4
PHF1
PICK1
PIN1
PLEKHA7
PPP1R16A
PRAM1
PRDM16
PRDM6
PRDX3
PRICKLE4
PTN
PTPN21
PTPRD
RBAK
RBBP6
RIMBP3C
RPS6KB1
RPS7
SAXO1
SGK1
SH3RF2
SMAD4
SMUG1
SMURF2
SORBS3
SPRY3
TASOR2
TCF12
TCF4
TEPSIN
TEX45
TFIP11
TGFBR1
TLE5
TNK2
TRAF2
TRIM23
TRIM27
TRIM54
TRIP4
UBXN11
XIAP
ZC2HC1C
ZCCHC7
ZFP90
ZNF24
ZNF343
ZNF438
ZNF587
ZNF688
ZNF774
ZRANB1
292 interacting genes:
ADAM12
ADAMTSL4
AGXT
ALG13
ALPP
AMMECR1
AMOT
ANKS1A
ARID5A
ARMC7
ATG9B
ATP23
BAG4
BAHD1
BATF2
BHLHB9
BLCAP
BLZF1
BSCL2
BUD31
C11orf1
C11orf16
CATSPER1
CCDC120
CCDC33
CCN3
CCN4
CCN5
CCNK
CD164
CDPF1
CERCAM
CFP
CHIC2
CHRD
CHRDL2
CNFN
CNNM3
COL8A1
CREB5
CUTA
CXCL16
CYHR1
CYP21A2
CYSRT1
DOCK2
DOCK3
DOK3
DTX2
DUSP10
DUSP22
EFEMP1
EFEMP2
EGFL7
ENKD1
EPDR1
ESM1
ESR2
EVA1B
FAAP100
FAM219B
FAM221A
FBLN1
FHL3
FHL5
FOXH1
FOXN1
FRS3
FST
FUCA2
GAS8
GATA1
GCM2
GDF15
GNE
GP9
GPS2
GRN
GSTP1
GUCD1
HEXB
HEXIM2
HEY2
HOXB9
HR
HSD3B7
ID3
IGFL1
IGFN1
INCA1
INO80B
IRX6
ITGB4
KCTD9
KDM1A
KPRP
KRT31
KRT33B
KRT34
KRT35
KRT37
KRT38
KRT40
KRT81
KRT82
KRT83
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-3
KRTAP10-4
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-2
KRTAP13-3
KRTAP13-4
KRTAP15-1
KRTAP19-6
KRTAP19-7
KRTAP2-3
KRTAP2-4
KRTAP23-1
KRTAP26-1
KRTAP3-2
KRTAP3-3
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-2
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LASP1
LCE1A
LCE1B
LCE1C
LCE1D
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3C
LCE3E
LCE4A
LCE5A
LGALS13
LGALS4
LMX1B
LNX1
LONRF1
LPXN
MACO1
MAPKBP1
MDFI
MFAP2
MGAT5B
MKRN3
MYO15B
MYPOP
N4BP2L2
NBPF19
NCK2
NECTIN2
NEDD9
NEK6
NELL2
NFKBID
NOTCH2NLA
NR1D2
NTN4
NXF1
ODF1
OIT3
P2RY6
PAX6
PBX2
PCSK5
PCYOX1
PHETA1
PIK3R1
PIN1
PITX1
PITX2
PKNOX1
PLEKHN1
PLLP
PLSCR1
PLSCR2
PLSCR3
PLSCR4
PPP1R32
PRICKLE4
PRMT6
PROP1
PSMB1
PTH1R
PVR
QARS1
RALGDS
RANBP3
RBCK1
RBP3
RBPMS
RCHY1
RGS17
RGS19
RGS20
RNF208
RSPO2
RTN4R
SCT
SDCBP
SIVA1
SLC15A3
SLC23A1
SLIT1
SLPI
SNRPB
SNRPC
SPATA12
SPATA18
SPRY1
SPRY2
SPRY3
SPRY4
SSC4D
SSUH2
STX11
SUV39H1
TBC1D10C
TBX15
TCF19
TCF3
TEKT4
TEKT5
TGFB1
TGM7
THAP7
TLE5
TNS2
TRAF1
TRAF2
TRAF4
TRAPPC6A
TRIM42
TRIM55
TRIM63
TRIM8
TRIP6
TSPAN4
UBL5
UNKL
VASN
VWC2
VWC2L
WDR83
WWOX
YIPF3
YPEL3
ZBTB16
ZIM2
ZMAT1
ZNF417
ZNF587
ZNF688
ZNF774
ZNF837
ZNF843
Entrez ID
10783
3198
HPRD ID
05348
00843
Ensembl ID
ENSG00000119408
ENSG00000105991
Uniprot IDs
A0A024R8A6
Q9HC98
P49639
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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