SPRY3 and HR

Data Source:
BioGRID (two hybrid)

		SPRY3	HR
Description		sprouty RTK signaling antagonist 3	HR lysine demethylase and nuclear receptor corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Histone Deacetylase Complex Chromatin Nucleoplasm
	Molecular Function	Molecular_function Protein Binding	Transcription Coregulator Activity Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding
	Biological Process	Multicellular Organism Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Axon Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neuron Projection Arborization	Regulation Of Transcription By RNA Polymerase II Histone H3-K9 Demethylation
Pathways
Drugs
Diseases			Atrichia with papular lesions Localized autosomal recessive hypotrichosis Marie-Unna hereditary hypotrichosis (MUHH)
GWAS		Idiopathic osteonecrosis of the femoral head ( 28000841) Iron status biomarkers (transferrin saturation) ( 28334935)	Obesity-related traits ( 23251661)
Interacting Genes		27 interacting genes: AQP1 BEX2 CATSPER1 CHRD CREB5 GNE GPSM3 HOXA1 HR KPRP KRT34 LCE1A LCE1B LCE1F LCE2B LCE3A LCE3D LCE3E MAPKBP1 MEOX2 NEK6 R3HDM2 SLC39A7 VSNL1 ZDHHC17 ZNF587 ZNF655	35 interacting genes: AMMECR1 ATP23 C11orf1 C19orf54 CNFN CYSRT1 FAM168A GEMIN4 HDAC1 HDAC3 HDAC5 HMGB1 HOXA1 INCA1 KLHL20 KRTAP11-1 KRTAP13-2 KRTAP15-1 KRTAP3-1 KRTAP3-3 KRTAP6-3 MGAT5B PLA2G10 PRKCA RARA RARB RBP3 SPAG8 SPRY3 TBL1X TRIM27 TSC1 VDR YPEL3 ZMYND12
Entrez ID		10251	55806
HPRD ID		03917	03808
Ensembl ID		ENSG00000168939	ENSG00000168453
Uniprot IDs		O43610 Q6ZUP3	O43593
PDB IDs
Enriched GO Terms of Interacting Partners?
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