SPRY3 and CHRD

Data Source:
BioGRID (two hybrid)

		SPRY3	CHRD
Description		sprouty RTK signaling antagonist 3	chordin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Extracellular Space
	Molecular Function	Molecular_function Protein Binding	Protein Binding Cytokine Binding
	Biological Process	Multicellular Organism Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Axon Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neuron Projection Arborization	Skeletal System Development Positive Regulation Of Mesenchymal Cell Proliferation BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion
Pathways
Drugs
Diseases
GWAS		Idiopathic osteonecrosis of the femoral head ( 28000841) Iron status biomarkers (transferrin saturation) ( 28334935)	Diisocyanate-induced asthma ( 25918132) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet count ( 32888494 20139978) Plateletcrit ( 32888494 27863252)
Interacting Genes		27 interacting genes: AQP1 BEX2 CATSPER1 CHRD CREB5 GNE GPSM3 HOXA1 HR KPRP KRT34 LCE1A LCE1B LCE1F LCE2B LCE3A LCE3D LCE3E MAPKBP1 MEOX2 NEK6 R3HDM2 SLC39A7 VSNL1 ZDHHC17 ZNF587 ZNF655	57 interacting genes: ADAMTSL4 ATN1 BMP1 BMP2 CATSPER1 CD36 CHRDL2 CYSRT1 F2R GATA1 HOXA1 HRG INCA1 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-1 KRTAP19-2 KRTAP19-5 KRTAP22-1 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 LCE1C LCE1F LCE5A LIN7A MEOX2 NBPF19 NOTCH2NLA NR0B2 NR4A3 OTX1 PLSCR1 POU4F2 RGS17 SLC15A2 SMAD3 SPRY1 SPRY2 SPRY3 TLL1 TRIM42 TSPAN4 TWSG1
Entrez ID		10251	8646
HPRD ID		03917	04592
Ensembl ID		ENSG00000168939	ENSG00000090539
Uniprot IDs		O43610 Q6ZUP3	E7ESX1 Q8N2W7 Q9H2X0
PDB IDs
Enriched GO Terms of Interacting Partners?
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