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NEK6 and TFIP11
Data Source:
BioGRID
(two hybrid)
NEK6
TFIP11
Description
NIMA related kinase 6
tuftelin interacting protein 11
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Microtubule
Nuclear Speck
Protein-containing Complex
Centriolar Satellite
Chromosome, Telomeric Region
Nucleoplasm
Spliceosomal Complex
Nucleolus
Cytoplasm
Nuclear Speck
Extracellular Matrix
U2-type Post-mRNA Release Spliceosomal Complex
Catalytic Step 2 Spliceosome
Molecular Function
Magnesium Ion Binding
Transcription Corepressor Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinesin Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Activating Transcription Factor Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Nucleic Acid Binding
Protein Binding
Biological Process
Protein Phosphorylation
Apoptotic Process
Chromosome Segregation
Mitotic Nuclear Envelope Disassembly
Regulation Of Mitotic Cell Cycle
Peptidyl-serine Phosphorylation
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Protein Autophosphorylation
Spindle Assembly
Cell Division
Regulation Of Cellular Senescence
Spliceosomal Complex Disassembly
MRNA Splicing, Via Spliceosome
RNA Processing
Biomineral Tissue Development
Negative Regulation Of Protein-containing Complex Assembly
Protection From Non-homologous End Joining At Telomere
Negative Regulation Of Protein Binding
Negative Regulation Of DNA Ligase Activity
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
EML4 and NUDC in mitotic spindle formation
mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Asthma (
32296059
)
Asthma exacerbations in inhaled corticosteroid treatment (
30697902
)
Blond vs. brown/black hair color (
30531825
)
Chronotype (
30696823
)
Cognitive performance (
20125193
)
Free thyroxine concentration (
30367059
)
Heel bone mineral density (
30598549
)
Medication use (thyroid preparations) (
31015401
)
Mercury levels (
26025379
)
Neurociticism (
29500382
)
Pulse pressure (
30224653
)
Thyroid stimulating hormone levels (
32769997
)
Vitiligo (
27723757
)
Interacting Genes
117 interacting genes:
ANKRA2
ARHGAP33
ARRB1
ATF4
BEND7
BHLHE40
CBY2
CCDC120
CCDC136
CCDC85B
CDC42
CDK7
CEP76
CFP
CIR1
COG6
CTBP2
DDIT4L
DES
DPH2
EFHC2
ERCC6L2
FAM220A
FHL5
FOXJ3
GFAP
GIGYF1
GLIS3
GOLGA6L2
GRIP1
HOMEZ
HOOK2
HOXA1
HOXB6
HSD17B14
IHO1
IKZF1
IKZF3
INCA1
KATNBL1
KCTD5
KIAA1328
KRT31
KRT34
KRT40
KRT75
KRT8
KRTAP10-8
KRTAP13-1
KRTAP13-3
LNX1
LZTS1
LZTS2
MBD3L1
MEOX2
METTL15
MYOG
MYOZ3
NECAB2
NEFL
NEK9
NIF3L1
NUDT16L1
PAK6
PBX4
PHF1
PICK1
PIN1
PLEKHA7
PPP1R16A
PRAM1
PRDM16
PRDM6
PRDX3
PRICKLE4
PTN
PTPN21
PTPRD
RBAK
RBBP6
RIMBP3C
RPS6KB1
RPS7
SAXO1
SGK1
SH3RF2
SMAD4
SMUG1
SMURF2
SORBS3
SPRY3
TASOR2
TCF12
TCF4
TEPSIN
TEX45
TFIP11
TGFBR1
TLE5
TNK2
TRAF2
TRIM23
TRIM27
TRIM54
TRIP4
UBXN11
XIAP
ZC2HC1C
ZCCHC7
ZFP90
ZNF24
ZNF343
ZNF438
ZNF587
ZNF688
ZNF774
ZRANB1
232 interacting genes:
AARD
ABI2
ABLIM3
AIMP2
ANKRD11
AP1M1
ARHGEF9
ARMC7
ARMCX1
ARNT2
ATP5PO
ATPAF2
AXIN1
BAZ2B
BCL6
BHLHA9
BMF
BRD1
BYSL
C1orf109
C2CD6
CARD9
CAVIN3
CBX8
CCDC102B
CCDC116
CCDC120
CCDC121
CCDC13
CCDC146
CCDC187
CCDC196
CCDC42
CCDC57
CCDC6
CCDC68
CCDC96
CCHCR1
CCND3
CCNG1
CCNL1
CCP110
CDKN1A
CDR2L
CENPU
CEP57
CEP57L1
CEP95
CFAP206
COQ8A
COX5B
CT55
CWF19L2
DAXX
DDX25
DES
DGCR6
DISC1
DPPA3
DTNB
EAF2
EIF3A
EIF3D
ENOX2
EPM2AIP1
EXOC3L1
EXOC8
EXOSC5
FAM13C
FAM156A
FAM161A
FAM161B
FAM50B
FAM81A
FAM90A1
FANCG
FGA
GADD45GIP1
GAS2L2
GCC1
GCFC2
GEM
GFAP
GNG4
GOLGA1
GOLGA2
GPS2
GRAP2
GSE1
HAUS1
HDAC4
HIP1R
HMG20B
HOOK1
HSF2BP
IKBIP
IL16
IMP3
JRK
KANK2
KANSL1
KAT5
KDM1A
KIF3C
KIF9
KIFC3
KIZ
KRT1
KRT20
KRT6A
KRT6B
KRT6C
KRT8
LATS1
LCA5
LCA5L
LENG1
LIN37
LMNB2
LMO1
LMO2
LMO4
LSM3
LSP1P3
LYSMD1
MAB21L2
MCM7
MDM2
METTL17
MFAP1
MKRN3
MRPL11
MTFR2
MXD3
MYO15B
MYOM1
NDC80
NDE1
NDN
NEK6
NFKBID
NFU1
NSMF
NUP88
ODAD3
OIP5
PBX3
PBX4
PCM1
PDE4DIP
PHF1
PIBF1
PICK1
PKN3
PLK4
POLL
POLR1C
POM121
PPFIA3
PPP1R16A
PPP1R16B
PPP1R18
PRPF31
PSMA4
PSMC5
PSTPIP1
PTCD1
RCOR3
RHNO1
RIN1
RNF6
RRP7A
RUNX1T1
RXRB
S100P
SAP30BP
SCNM1
SFR1
SGF29
SH2D4A
SH3GLB1
SMARCB1
SMARCE1
SNAPIN
SNRPB
SNW1
SNX20
SNX32
SOGA1
SPG21
SSX2IP
STRA8
STRN
SYCE1
TBC1D30
TBRG4
TCAF1
TDP2
TFPT
THAP7
THAP8
TNNT1
TP53
TRAF3IP3
TRAPPC4
TRIM45
TRIML2
TSG101
TSGA10IP
TSHZ2
TSHZ3
TSPYL4
TUFT1
TXLNA
TXN2
UBTFL1
USP2
USP6
USP7
VPS37C
VPS39
WAC
WASHC3
ZC2HC1C
ZFYVE26
ZGPAT
ZMAT2
ZNF417
ZNF572
ZNF587
ZNF777
ZSCAN12
Entrez ID
10783
24144
HPRD ID
05348
11628
Ensembl ID
ENSG00000119408
ENSG00000100109
Uniprot IDs
A0A024R8A6
Q9HC98
A0A024R1I7
Q9UBB9
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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