SLC9A3R1 and SLC4A8

Number of citations of the paper that reports this interaction (PMID 12444018)
11

Data Source:
HPRD (in vitro)

		SLC9A3R1	SLC4A8
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	solute carrier family 4, sodium bicarbonate cotransporter, member 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Membrane Neuron Projection
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	Inorganic Anion Exchanger Activity Sodium:bicarbonate Symporter Activity
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Ion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Transmembrane Transport Anion Transmembrane Transport
Pathways			Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Bicarbonate transporters
Drugs
Diseases
GWAS		Fibrinogen ( 20031577)	Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	3 interactors: CA2 CFTR SLC9A3R1
Entrez ID		9368	9498
HPRD ID		05406	05430
Ensembl ID		ENSG00000109062	ENSG00000050438
Uniprot IDs		O14745	B4DHY0 E7EML0 F5GZ31 Q2Y0W8
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Regulation Of Chloride Transport Bicarbonate Transport Organic Anion Transport Cellular Ion Homeostasis Regulation Of Intracellular PH Regulation Of Cellular PH Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Ion Transport Anion Transport Cellular Homeostasis Regulation Of PH Chemical Homeostasis Regulation Of Anion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Renal Phosphate Ion Absorption Positive Regulation Of Voltage-gated Chloride Channel Activity Homeostatic Process Response To Estrogen Positive Regulation Of Dipeptide Transmembrane Transport Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Ion Transport Positive Regulation Of Cellular PH Reduction Lipid Transport Lipid Localization Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Iodide Transport Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Angiotensin-activated Signaling Pathway Transepithelial Chloride Transport Regulation Of Ion Transmembrane Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Cation Homeostasis Response To Steroid Hormone Bile Acid Secretion Oligopeptide Transport Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Transepithelial Transport Intracellular PH Elevation Phosphate Ion Homeostasis Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, GABAergic
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	adaptive beginning cb cch cerebellum cx decreases durations exchanger exhibits hc hco hypothesize nbcn1 nbcn2 ncbt ncbts ndcbe neonates normoxia p2 p90 polyclonal pyramidal rodent scx stabilizes subcortex transporters
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	adaptive beginning cb cch cerebellum cx decreases durations exchanger exhibits hc hco hypothesize nbcn1 nbcn2 ncbt ncbts ndcbe neonates normoxia p2 p90 polyclonal pyramidal rodent scx stabilizes subcortex transporters
Tagcloud (Intersection) ?