SLC9A3R1 and ABCC2

Number of citations of the paper that reports this interaction (PMID 12615054)
15

Data Source:
HPRD (in vitro)

		SLC9A3R1	ABCC2
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apical Plasma Membrane Intercellular Canaliculus
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity Protein Domain Specific Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Transport Drug Transmembrane Transport Response To Oxidative Stress Metabolic Process Response To Heat Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estrogen Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport
Pathways			ABC-family proteins mediated transport
Drugs			Adenosine triphosphate Sulfinpyrazone
Diseases
GWAS		Fibrinogen ( 20031577)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	10 interactors: AZIN1 CANX MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 UBQLN1
Entrez ID		9368	1244
HPRD ID		05406	03065
Ensembl ID		ENSG00000109062	ENSG00000023839
Uniprot IDs		O14745	Q92887
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Microvillus Assembly Microvillus Organization Protein Localization Renal Phosphate Ion Absorption Negative Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity Negative Regulation Of CGMP Biosynthetic Process Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Polyamine Transmembrane Transport Postsynaptic Density Assembly Guanylate Kinase-associated Protein Clustering Glutathione Transport Regulation Of Cytoskeleton Organization Negative Regulation Of Calcidiol 1-monooxygenase Activity Regulation Of Long Term Synaptic Depression Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Cell Volume Positive Regulation Of Hyaluronan Biosynthetic Process Regulation Of Chromosome Condensation Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Monocarboxylic Acid Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Catalytic Activity Cellular Protein Localization Regulation Of Transmembrane Transporter Activity Cellular Localization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Ion Transport Negative Regulation Of Vitamin D Biosynthetic Process Renal Sodium Ion Transport N-methyl-D-aspartate Receptor Clustering Vocal Learning Positive Regulation Of Synapse Structural Plasticity Negative Regulation Of Cytoskeleton Organization Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Transport Positive Regulation Of Ion Transport Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Positive Regulation Of Long-term Neuronal Synaptic Plasticity Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Nicotine Negative Regulation Of Catalytic Activity
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	24c 24t 388g 521c abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn ugt1a1 www
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	24c 24t 388g 521c abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn ugt1a1 www
Tagcloud (Intersection) ?