SLC9A3R1 and TRPC5

Number of citations of the paper that reports this interaction (PMID 10980202)
38

Data Source:
HPRD (in vivo, in vitro)

		SLC9A3R1	TRPC5
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	transient receptor potential cation channel, subfamily C, member 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Plasma Membrane Integral Component Of Plasma Membrane Calcium Channel Complex
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Calcium Ion Transport Nervous System Development Axon Guidance Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport
Pathways			Ion channel transport Axon guidance Role of second messengers in netrin-1 signaling TRP channels Stimuli-sensing channels Netrin-1 signaling
Drugs
Diseases
GWAS		Fibrinogen ( 20031577)	Smoking behavior ( 19247474)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	7 interactors: ITPR3 MX1 SLC9A3R1 STMN2 STMN3 TRPC1 TRPC4
Entrez ID		9368	7224
HPRD ID		05406	02273
Ensembl ID		ENSG00000109062	ENSG00000072315
Uniprot IDs		O14745	Q9UL62
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Calcium Ion Transmembrane Transport Metal Ion Transport Calcium Ion Transport Acid Secretion Cell Projection Organization Cation Transport Regulation Of Microtubule Polymerization Or Depolymerization Cellular Ion Homeostasis Renal Phosphate Ion Absorption Cellular Chemical Homeostasis Ion Homeostasis Response To Calcium Ion Generation Of Neurons Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Secretion Monocarboxylic Acid Transport Neurogenesis Regulation Of Microtubule Cytoskeleton Organization Cellular Homeostasis Ion Transport Regulation Of Microtubule-based Process Gamma-aminobutyric Acid Secretion Cytosolic Calcium Ion Homeostasis Neuron Projection Development Renal Sodium Ion Transport Positive Regulation Of Microtubule Depolymerization Chemical Homeostasis Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Sensory Perception Of Sweet Taste Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Cation Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Rac Protein Signal Transduction Sensory Perception Of Umami Taste Neuron Development Nervous System Development Phospholipase C-activating Dopamine Receptor Signaling Pathway Gamma-aminobutyric Acid Transport Saliva Secretion Bile Acid Secretion Microtubule Depolymerization Cellular Calcium Ion Homeostasis Neuron Differentiation Carboxylic Acid Transport Calcium Ion Homeostasis Organic Acid Transport Oligopeptide Transport Negative Regulation Of Sodium Ion Transport
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	allosteric ankyrin arises belongs branched channels detectors enthalpy evolved gating kcal macroscopic melastatin polymodal specialized subfamilies tetramers thermal trpa trpa1 trpm trpm8 trpv trpv1 trpv3 vanilloid voltage
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	allosteric ankyrin arises belongs branched channels detectors enthalpy evolved gating kcal macroscopic melastatin polymodal specialized subfamilies tetramers thermal trpa trpa1 trpm trpm8 trpv trpv1 trpv3 vanilloid voltage
Tagcloud (Intersection) ?