SLC9A3R1 and SLC22A11

Number of citations of the paper that reports this interaction (PMID 16236806)
11

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SLC9A3R1	SLC22A11
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	solute carrier family 22 (organic anion/urate transporter), member 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	Inorganic Anion Exchanger Activity Protein Binding Organic Anion Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Organic Anion Transport Urate Metabolic Process Transmembrane Transport
Pathways			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Organic anion transport Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport
Drugs			Probenecid
Diseases
GWAS		Fibrinogen ( 20031577)	Obesity-related traits ( 23251661) Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	3 interactors: CAV3 PDZK1 SLC9A3R1
Entrez ID		9368	55867
HPRD ID		05406	06161
Ensembl ID		ENSG00000109062	ENSG00000168065
Uniprot IDs		O14745	Q9NSA0
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Ion Transport Regulation Of Sodium Ion Transport Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Ion Transport Regulation Of Protein Kinase B Signaling Monocarboxylic Acid Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Protein Localization To Plasma Membrane Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Sarcomere Organization Renal Phosphate Ion Absorption Regulation Of Nerve Growth Factor Receptor Activity Negative Regulation Of MAPK Cascade Cellular Protein Localization Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Plasma Membrane Organization Establishment Of Protein Localization To Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development T-tubule Organization Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Carboxylic Acid Transport Organic Acid Transport Protein Localization Renal Sodium Ion Transport Regulation Of Membrane Depolarization During Action Potential Cellular Phosphate Ion Homeostasis Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Cardiac Muscle Cell Differentiation Protein Localization To Membrane Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Transport Negative Regulation Of Phosphorylation Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Caveolin-mediated Endocytosis Caveola Assembly Negative Regulation Of Intracellular Signal Transduction Endomembrane System Organization Negative Regulation Of Protein Localization To Cell Surface
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 urate zealand
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 urate zealand
Tagcloud (Intersection) ?