SLC9A3R1 and EGFR

Number of citations of the paper that reports this interaction (PMID 16456542)
54

Data Source:
HPRD (in vitro)

		SLC9A3R1	EGFR
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	epidermal growth factor receptor
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Golgi Membrane Extracellular Space Nucleus Cytoplasm Endosome Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Cell Surface Endosome Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Nuclear Membrane Receptor Complex Membrane Raft Perinuclear Region Of Cytoplasm Shc-EGFR Complex
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	Glycoprotein Binding Chromatin Binding Double-stranded DNA Binding MAP Kinase Kinase Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Epidermal Growth Factor-activated Receptor Activity Integrin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Nitric-oxide Synthase Regulator Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Heterodimerization Activity Epidermal Growth Factor Binding Actin Filament Binding
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	MAPK Cascade Activation Of MAPKK Activity Ossification Liver Development Embryonic Placenta Development Positive Regulation Of Protein Phosphorylation Hair Follicle Development Translation Response To Stress Response To Osmotic Stress Response To Oxidative Stress Signal Transduction Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Axon Guidance Salivary Gland Morphogenesis Learning Or Memory Circadian Rhythm Cell Proliferation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Magnesium Ion Homeostasis Diterpenoid Metabolic Process Single Organismal Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Alkanesulfonate Metabolic Process Cerebral Cortex Cell Migration Lung Development Positive Regulation Of Cell Migration Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Response To Cobalamin Response To Hydroxyisoflavone Positive Regulation Of Catenin Import Into Nucleus Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Positive Regulation Of Phosphorylation Ovulation Cycle Hydrogen Peroxide Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Tongue Development Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Astrocyte Activation Positive Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Nitric-oxide Synthase Activity Protein Insertion Into Membrane Response To Calcium Ion Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Synaptic Transmission, Glutamatergic Morphogenesis Of An Epithelial Fold Response To UV-A Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Dexamethasone Stimulus
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K/AKT activation PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Signaling by PDGF EGFR downregulation DAP12 interactions GAB1 signalosome GRB2 events in EGFR signaling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Adaptive Immune System Axon guidance PIP3 activates AKT signaling L1CAM interactions EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signalling by NGF Signal transduction by L1 Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Inhibition of Signaling by Overexpressed EGFR Signaling by FGFR SHC1 events in EGFR signaling Constitutive Signaling by EGFRvIII
Drugs			Cetuximab Trastuzumab Lidocaine Gefitinib Erlotinib Lapatinib Panitumumab Flavopiridol Vandetanib S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE Afatinib
Diseases
GWAS		Fibrinogen ( 20031577)	Glioma ( 21531791)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	279 interactors: ABL1 ABL2 ACTA1 ADRBK1 ADRM1 AGTR1 AHNAK AHSA1 AIP AKAP12 ALCAM ALDOA AMH ANKS1A ANKS1B ANXA1 APBA3 APBB1 APBB2 APBB3 APPL1 AR AREG ARF4 ATIC ATP1A1 ATP1B1 ATP5C1 BLK BMX BTC CALM1 CALM2 CALM3 CAMK2A CAMK2G CAMLG CASP1 CAV1 CAV2 CAV3 CBL CBLB CBLC CBR1 CD44 CD59 CD82 CDC25A CDH1 CEACAM1 CEBPB CEND1 CFL1 CISH CLNK CLTA CLTCL1 CMTM8 CNTN2 COL9A3 COX2 CRK CSRP1 CTNNB1 CTNND1 DCBLD2 DCN DCTN2 DEGS1 DNAJC4 DOK2 DOK4 DOK5 DOK6 DUSP3 DYNC1H1 EEF1G EGF ELF3 EPB41 EPHA2 EPPK1 EPS15 EPS8 ERBB2 ERBB3 ERBB4 EREG ERRFI1 ESR1 EZR FAH FAS FBXO25 FER FES FKBP4 FKBP8 FN1 GAB1 GABARAPL2 GAPDH GNAI2 GOT1 GPM6B GRB10 GRB14 GRB2 GRB7 HBEGF HEXIM1 HGS HIST3H3 HOXC10 HSP90B1 HSPA1A HSPA4 HSPA8 HTT ICAM1 INPPL1 IRS1 IRS4 ITGA5 JAK2 JUP KCTD9P2 KRT17 KRT18 KRT7 KRT8 LYN MAP2K1 MAP3K12 MAP3K14 MAP4K1 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAST1 MATR3 MDH1 MEGF6 MET MGARP MOB4 MUC1 NCAM1 NCK1 NCK2 NDN NEDD4 NUMB NUMBL OAZ1 OLFM1 PAK1 PCNA PDCD6IP PDGFRB PDK3 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PIN4 PITPNA PKIA PLCG1 PLCG2 PLD1 PLD2 PLEC PLSCR1 PML PPP5C PRCC PRDX1 PRKACA PRKAR1A PRKAR1B PRKCA PRKCB PRKCD PRKD1 PSMA7 PSMD4 PTGDS PTK2 PTK2B PTK6 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRJ PTPRS RAB3A RAP1GDS1 RASA1 RGS16 RIN2 RIPK1 RNF115 RNF126 RQCD1 RUSC2 S100A7 S100A9 SCAMP1 SCAMP3 SEC13 SEPP1 SFN SGSM2 SH2B1 SH2B3 SH2D1A SH2D2A SH2D3A SH3BGRL3 SHC1 SHC2 SHC3 SLA SLC3A2 SLC9A3R1 SMURF2 SNRPD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS3 SOCS4 SOCS5 SOCS7 SORBS2 SOS1 SOS2 SPARCL1 SPCS2 SRC STAM2 STAT1 STAT3 STAT5A STAT5B STIP1 SYK TGFA TJP1 TLN1 TMCO3 TNC TNK2 TNS4 TPI1 TPM1 TRPV1 TUBA1A TUBA4A UBB UBE2V2 UCHL1 UROD VAPA VAV1 VAV2 VAV3 XRCC6 YWHAZ ZAP70 ZPR1
Entrez ID		9368	1956
HPRD ID		05406	00579
Ensembl ID		ENSG00000109062	ENSG00000146648
Uniprot IDs		O14745	E9PFD7 P00533
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF	1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2EB2 2EB3 2EXP 2EXQ 2GS2 2GS6 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F 2J6M 2JIT 2JIU 2JIV 2KS1 2M20 2RF9 2RFD 2RFE 2RGP 3B2U 3B2V 3BEL 3BUO 3C09 3G5V 3G5Y 3GOP 3GT8 3IKA 3LZB 3NJP 3OB2 3OP0 3P0Y 3PFV 3POZ 3QWQ 3UG1 3UG2 3VJN 3VJO 3VRP 3VRR 3W2O 3W2P 3W2Q 3W2R 3W2S 3W32 3W33 4G5J 4G5P 4HJO 4I1Z 4I20 4I21 4I22 4I23 4I24 4JQ7 4JQ8 4JR3 4JRV 4KRL 4KRM 4KRO 4KRP 4LI5 4LL0
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organic Substance Regulation Of Signal Transduction Response To Stress Cellular Response To Stimulus Cell Communication Cellular Response To Organic Substance Signaling Signal Transduction Innate Immune Response Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Defense Response Wound Healing Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Immune System Process Regulation Of Catalytic Activity Response To Wounding Intracellular Signal Transduction Immune Response Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Neurotrophin TRK Receptor Signaling Pathway Locomotion Regulation Of Protein Phosphorylation Movement Of Cell Or Subcellular Component Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound System Development Response To Organonitrogen Compound Regulation Of Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Anatomical Structure Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Cellular Response To Peptide
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?