SLC9A3R1 and SLC34A1

Number of citations of the paper that reports this interaction (PMID 11099500)
37

Data Source:
HPRD (in vitro)

		SLC9A3R1	SLC34A1
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Membrane-bounded Vesicle Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	Protein Binding Symporter Activity Sodium-dependent Phosphate Transmembrane Transporter Activity PDZ Domain Binding Protein Complex Binding Protein Homodimerization Activity
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Ossification Kidney Development Ion Transport Sodium Ion Transport Phosphate Ion Transport Glycoprotein Metabolic Process Response To Lead Ion Response To Magnesium Ion Response To Estradiol Response To Vitamin A Response To Potassium Ion Indole Metabolic Process Response To Drug Sodium-dependent Phosphate Transport Positive Regulation Of Membrane Potential Response To Cadmium Ion Response To Mercury Ion Bone Remodeling Protein Homooligomerization Phosphate Ion Homeostasis Transmembrane Transport Response To Growth Hormone Cellular Response To Metal Ion Cellular Response To Parathyroid Hormone Stimulus Tricarboxylic Acid Metabolic Process Cellular Response To Staurosporine Response To Thyroid Hormone Dentinogenesis Gentamycin Metabolic Process Arsenate Ion Transmembrane Transport Positive Regulation Of Sodium-dependent Phosphate Transport Positive Regulation Of Phosphate Transmembrane Transport
Pathways			Sodium-coupled phosphate cotransporters Type II Na+/Pi cotransporters Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Fibrinogen ( 20031577)	Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Nephrolithiasis ( 22396660)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	10 interactors: BSPRY FHL2 HPCAL1 HSP90AA1 HSP90AB1 MAST2 PEX19 SLC9A3R1 SLC9A3R2 YIF1A
Entrez ID		9368	6569
HPRD ID		05406	08918
Ensembl ID		ENSG00000109062	ENSG00000131183
Uniprot IDs		O14745	Q06495 Q7Z725 Q86VN6
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Unfolded Protein Regulation Of Cellular Response To Heat Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Folding Intracellular Protein Transmembrane Transport Regulation Of Nitric Oxide Biosynthetic Process Protein Transmembrane Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Heat Renal Phosphate Ion Absorption Negative Regulation Of Lipid Binding Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Response To Heat Atrial Cardiac Muscle Cell Development Peroxisome Membrane Biogenesis Protein Import Into Mitochondrial Outer Membrane Regulation Of Reactive Oxygen Species Metabolic Process Protein Import Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Response To Temperature Stimulus Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Protein Kinase Activity Intracellular Receptor Signaling Pathway Protein Import Into Peroxisome Membrane Chaperone-mediated Protein Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Peroxisomal Membrane Transport Regulation Of Kinase Activity Establishment Of Protein Localization To Membrane Bile Acid Secretion Peroxisome Fission Oligopeptide Transport Regulation Of Binding Phagocytosis Positive Regulation Of Protein Import Into Nucleus, Translocation Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted
Tagcloud (Intersection) ?