SLC9A3R1 and NOS2

Number of citations of the paper that reports this interaction (PMID 12080081)
11

Data Source:
HPRD (in vivo, in vitro)

		SLC9A3R1	NOS2
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	nitric oxide synthase 2, inducible
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Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Intracellular Nucleus Cytoplasm Peroxisome Cytosol Cortical Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Receptor Binding Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Heme Binding Tetrahydrobiopterin Binding Arginine Binding Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Innate Immune Response In Mucosa Arginine Catabolic Process Superoxide Metabolic Process Nitric Oxide Biosynthetic Process Inflammatory Response Nitric Oxide Mediated Signal Transduction Blood Coagulation Circadian Rhythm Response To Bacterium Negative Regulation Of Gene Expression Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Regulation Of Cell Proliferation Negative Regulation Of Protein Catabolic Process Defense Response To Bacterium Regulation Of Cellular Respiration Negative Regulation Of Blood Pressure Positive Regulation Of Vasodilation Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Interaction With Host Positive Regulation Of Killing Of Cells Of Other Organism Oxidation-reduction Process Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Phagosome Maturation
Pathways			Platelet homeostasis Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Nitric oxide stimulates guanylate cyclase
Drugs			L-Arginine L-Citrulline Miconazole Dexamethasone N,N-dimethylarginine 4r-Fluoro-N6-Ethanimidoyl-L-Lysine 3-Bromo-7-Nitroindazole N-(3-(Aminomethyl)Benzyl)Acetamidine 7-Nitroindazole Ethylisothiourea Thiocoumarin Aminoguanidine S-Ethylisothiourea N-Omega-Propyl-L-Arginine (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin Heme 6-Nitroindazole N-Omega-Hydroxy-L-Arginine 7,8-Dihydro-L-Biopterin N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine L-Thiocitrulline 7,8-Dihydrobiopterin 5-Nitroindazole 5-(4\'-AMINO-1\'-ETHYL-5\',8\'-DIFLUORO-1\'H-SPIRO[PIPERIDINE-4,2\'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE 1-(6-CYANO-3-PYRIDYLCARBONYL)-5\',8\'-DIFLUOROSPIRO[PIPERIDINE-4,2\'(1\'H)-QUINAZOLINE]-4\'-AMINE 4-(1H-IMIDAZOL-1-YL)PHENOL 1-[4-(AMINOMETHYL)BENZOYL]-5\'-FLUORO-1\'H-SPIRO[PIPERIDINE-4,2\'-QUINAZOLIN]-4\'-AMINE Triflusal
Diseases
GWAS		Fibrinogen ( 20031577)	Crohn's disease ( 23128233) Psoriasis ( 20953189)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	11 interactors: ACTB ACTN4 CAV1 PEX5 RAC1 RAC2 SLC9A3R1 SPSB1 SPSB2 SPSB4 SRC
Entrez ID		9368	4843
HPRD ID		05406	01225
Ensembl ID		ENSG00000109062	ENSG00000007171
Uniprot IDs		O14745	P35228
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF	1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4NOS
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Vascular Endothelial Growth Factor Receptor Signaling Pathway Wound Healing Tissue Remodeling Cellular Component Assembly Regulation Of Cellular Component Movement Response To Wounding Bone Resorption Tissue Homeostasis Regulation Of Endocytosis Cell-cell Junction Organization Bone Remodeling Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Protein Homooligomerization Signal Transduction Multicellular Organismal Homeostasis Actin Cytoskeleton Organization Intracellular Signal Transduction Signaling T Cell Costimulation Actin Filament-based Process Cell Communication Negative Regulation Of Protein Oligomerization Cell Activation Locomotion Actin Filament Organization Regulation Of Hydrogen Peroxide Metabolic Process Organelle Organization Ephrin Receptor Signaling Pathway Regulation Of Respiratory Burst Homeostatic Process Positive Regulation Of Cellular Component Movement Regulation Of Proton Transport Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Anoikis Regulation Of Vesicle-mediated Transport Regulation Of Cell Projection Assembly Movement Of Cell Or Subcellular Component Axon Guidance Membrane Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Lamellipodium Organization Regulation Of Anoikis Positive Regulation Of Immune System Process Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	17q 2q35 5p 6p 9p bcg candidates demonstration dichotomy exacerbation examines helper histocompatibility il4 immunology inbred ity leishmania leishmanial leishmaniasis lsh mexicana mip1 nramp1 parasites pleiotropic positionally reflecting sigje
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	17q 2q35 5p 6p 9p bcg candidates demonstration dichotomy exacerbation examines helper histocompatibility il4 immunology inbred ity leishmania leishmanial leishmaniasis lsh mexicana mip1 nramp1 parasites pleiotropic positionally reflecting sigje
Tagcloud (Intersection) ?