SLC9A3R1 and CNGA2

Number of citations of the paper that reports this interaction (PMID 14604981)
22

Data Source:
HPRD (in vitro, two hybrid)

		SLC9A3R1	CNGA2
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	cyclic nucleotide gated channel alpha 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece	Golgi Membrane Integral Component Of Plasma Membrane Golgi-associated Vesicle Membrane Ciliary Membrane
	Molecular Function	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding	Intracellular CGMP Activated Cation Channel Activity Voltage-gated Potassium Channel Activity Calmodulin Binding CAMP Binding CGMP Binding
	Biological Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Organelle Organization Phototransduction, Visible Light Sensory Perception Of Smell Regulation Of Membrane Potential Potassium Ion Transmembrane Transport
Pathways			Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium
Drugs
Diseases
GWAS		Fibrinogen ( 20031577)
Protein-Protein Interactions		52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468	2 interactors: CALM1 SLC9A3R1
Entrez ID		9368	1260
HPRD ID		05406	08946
Ensembl ID		ENSG00000109062	ENSG00000183862
Uniprot IDs		O14745	B3KXY3 Q16280
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process	Negative Regulation Of Transporter Activity Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Renal Phosphate Ion Absorption Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Negative Regulation Of Transport Negative Regulation Of Phosphorylation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of High Voltage-gated Calcium Channel Activity Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Ion Transport Secretion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Bile Acid Secretion Detection Of Calcium Ion Oligopeptide Transport Regulation Of Protein Kinase Activity Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphoprotein Phosphatase Activity Phosphate Ion Homeostasis Regulation Of Kinase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Assembly Microvillus Organization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity
Tagcloud ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	activators automated campaign cation cgmp coculture cofactor cyclase cyclic enos gained gated guanosine guanylyl homogeneous indirectly influx living makes monophosphate nitric olfactory reflects reporter sensor sgc stimulators throughput
Tagcloud (Difference) ?		adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted	activators automated campaign cation cgmp coculture cofactor cyclase cyclic enos gained gated guanosine guanylyl homogeneous indirectly influx living makes monophosphate nitric olfactory reflects reporter sensor sgc stimulators throughput
Tagcloud (Intersection) ?