REPS2 and ASAP1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		REPS2	ASAP1
Description		RALBP1 associated Eps domain containing 2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Podosome Cytosol Cell Projection Membrane Dendritic Spine
	Molecular Function	Calcium Ion Binding Protein Binding	Phosphatidylserine Binding GTPase Activator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Cadherin Binding Metal Ion Binding
	Biological Process	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Membrane Organization Protein-containing Complex Assembly	Positive Regulation Of GTPase Activity Cilium Assembly Negative Regulation Of Dendritic Spine Development Positive Regulation Of Podosome Assembly Positive Regulation Of Membrane Tubulation
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS			Diisocyanate-induced asthma ( 25918132) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Multiple sclerosis ( 19525955) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Progressive supranuclear palsy ( 30089514) Refractive error ( 32231278) Tuberculosis ( 25774636) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		13 interacting genes: AR ASAP1 ASAP2 CDK1 CDK5RAP2 EPN1 EPS15 GRB2 PXN RALB RALBP1 RELA REPS1	15 interacting genes: ARF1 ARF6 CBL CRK DNAJB6 GRB2 HCK PACSIN3 PTK2 PTK2B PXN RAB11FIP3 REPS2 SH3KBP1 SRC
Entrez ID		9185	50807
HPRD ID		02262	05809
Ensembl ID		ENSG00000169891	ENSG00000153317
Uniprot IDs		Q8NFH8	A0A0A0MRE5 Q9ULH1
PDB IDs		1IQ3	2D1X 2DA0 2ED1 2RQT 2RQU
Enriched GO Terms of Interacting Partners?
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