REPS2 and EPN1

Data Source:
HPRD (in vivo, in vitro)

		REPS2	EPN1
Description		RALBP1 associated Eps domain containing 2	epsin 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Endosome Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat Intracellular Membrane-bounded Organelle
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Binding Phospholipid Binding Clathrin Binding
	Biological Process	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Membrane Organization Protein-containing Complex Assembly	Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS			Major depressive disorder ( 23377640)
Interacting Genes		13 interacting genes: AR ASAP1 ASAP2 CDK1 CDK5RAP2 EPN1 EPS15 GRB2 PXN RALB RALBP1 RELA REPS1	25 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16
Entrez ID		9185	29924
HPRD ID		02262	06270
Ensembl ID		ENSG00000169891	ENSG00000063245
Uniprot IDs		Q8NFH8	A0A024R4S1 Q9Y6I3
PDB IDs		1IQ3	1INZ 1KYD
Enriched GO Terms of Interacting Partners?
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