ASAP1 and PACSIN3

Data Source:
HPRD (two hybrid)

		ASAP1	PACSIN3
Description		ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	protein kinase C and casein kinase substrate in neurons 3
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Cytosol Cell Projection Membrane Dendritic Spine	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding GTPase Activator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Cadherin Binding Metal Ion Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding
	Biological Process	Positive Regulation Of GTPase Activity Cilium Assembly Negative Regulation Of Dendritic Spine Development Positive Regulation Of Podosome Assembly Positive Regulation Of Membrane Tubulation	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Multiple sclerosis ( 19525955) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Progressive supranuclear palsy ( 30089514) Refractive error ( 32231278) Tuberculosis ( 25774636) Waist circumference adjusted for body mass index ( 28552196)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		15 interacting genes: ARF1 ARF6 CBL CRK DNAJB6 GRB2 HCK PACSIN3 PTK2 PTK2B PXN RAB11FIP3 REPS2 SH3KBP1 SRC	23 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNPO2 TRPV4 WASL
Entrez ID		50807	29763
HPRD ID		05809	05937
Ensembl ID		ENSG00000153317	ENSG00000165912
Uniprot IDs		A0A0A0MRE5 Q9ULH1	Q9UKS6
PDB IDs		2D1X 2DA0 2ED1 2RQT 2RQU
Enriched GO Terms of Interacting Partners?
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