ASAP1 and DNAJB6

Data Source:
BioGRID (two hybrid)

		ASAP1	DNAJB6
Description		ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	DnaJ heat shock protein family (Hsp40) member B6
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GO Annotations	Cellular Component	Podosome Cytosol Cell Projection Membrane Dendritic Spine	Nucleus Nucleoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylserine Binding GTPase Activator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Cadherin Binding Metal Ion Binding	ATPase Activator Activity Protein Binding Heat Shock Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Positive Regulation Of GTPase Activity Cilium Assembly Negative Regulation Of Dendritic Spine Development Positive Regulation Of Podosome Assembly Positive Regulation Of Membrane Tubulation	Protein Folding Positive Regulation Of ATPase Activity Regulation Of Protein Localization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intermediate Filament Organization Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Multiple sclerosis ( 19525955) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Progressive supranuclear palsy ( 30089514) Refractive error ( 32231278) Tuberculosis ( 25774636) Waist circumference adjusted for body mass index ( 28552196)	Body mass index ( 28552196) Retinal detachment or retinal break ( 31816047) Waist circumference ( 28552196)
Interacting Genes		15 interacting genes: ARF1 ARF6 CBL CRK DNAJB6 GRB2 HCK PACSIN3 PTK2 PTK2B PXN RAB11FIP3 REPS2 SH3KBP1 SRC	23 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MLF2 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8
Entrez ID		50807	10049
HPRD ID		05809	07107
Ensembl ID		ENSG00000153317	ENSG00000105993
Uniprot IDs		A0A0A0MRE5 Q9ULH1	A0A0J9YX62 O75190
PDB IDs		2D1X 2DA0 2ED1 2RQT 2RQU	6U3R 6U3S
Enriched GO Terms of Interacting Partners?
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