ASAP1 and REPS2

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ASAP1	REPS2
Description		ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	RALBP1 associated Eps domain containing 2
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GO Annotations	Cellular Component	Podosome Cytosol Cell Projection Membrane Dendritic Spine	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Phosphatidylserine Binding GTPase Activator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Cadherin Binding Metal Ion Binding	Calcium Ion Binding Protein Binding
	Biological Process	Positive Regulation Of GTPase Activity Cilium Assembly Negative Regulation Of Dendritic Spine Development Positive Regulation Of Podosome Assembly Positive Regulation Of Membrane Tubulation	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Membrane Organization Protein-containing Complex Assembly
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Multiple sclerosis ( 19525955) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Progressive supranuclear palsy ( 30089514) Refractive error ( 32231278) Tuberculosis ( 25774636) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		15 interacting genes: ARF1 ARF6 CBL CRK DNAJB6 GRB2 HCK PACSIN3 PTK2 PTK2B PXN RAB11FIP3 REPS2 SH3KBP1 SRC	13 interacting genes: AR ASAP1 ASAP2 CDK1 CDK5RAP2 EPN1 EPS15 GRB2 PXN RALB RALBP1 RELA REPS1
Entrez ID		50807	9185
HPRD ID		05809	02262
Ensembl ID		ENSG00000153317	ENSG00000169891
Uniprot IDs		A0A0A0MRE5 Q9ULH1	Q8NFH8
PDB IDs		2D1X 2DA0 2ED1 2RQT 2RQU	1IQ3
Enriched GO Terms of Interacting Partners?
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