CLDN2 and ADAM33

		CLDN2	ADAM33
Description		claudin 2	ADAM metallopeptidase domain 33
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane	Integral Component Of Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly	Proteolysis
Pathways		Tight junction interactions
Drugs
Diseases			Asthma
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)	Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		29 interacting genes: ADAM33 BTN3A2 CLEC2D CSGALNACT2 CXCL9 CYSRT1 EMP3 FAM209A GRM2 IGFBP5 IL27RA KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP4-12 LAT LNX1 LPAR3 MTDH NOTCH2NLA PIAS2 PLP1 TEX264 TJP1 TJP2 TMEM218 UBE2I WNK4	33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21
Entrez ID		9075	80332
HPRD ID		06471	06173
Ensembl ID		ENSG00000165376	ENSG00000149451
Uniprot IDs		P57739	A2A2L3 Q9BZ11
PDB IDs		4YYX	1R54 1R55
Enriched GO Terms of Interacting Partners?
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