CLDN2 and TJP2

Data Source:
BioGRID (two hybrid)

		CLDN2	TJP2
Description		claudin 2	tight junction protein 2
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane	Nucleus Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Cell-cell Contact Zone
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Guanylate Kinase Activity Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Cadherin Binding Cell Adhesion Molecule Binding Protein Tyrosine Kinase Binding
	Biological Process	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly	Homotypic Cell-cell Adhesion Hippo Signaling Maintenance Of Blood-brain Barrier Cell-cell Junction Organization GMP Metabolic Process GDP Metabolic Process Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Protein Localization To Cell-cell Junction Positive Regulation Of Blood-brain Barrier Permeability
Pathways		Tight junction interactions	Signaling by Hippo Apoptotic cleavage of cell adhesion proteins
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)	Macular thickness ( 30535121) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 23396134 32231278) Renal sinus fat ( 22044751) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		29 interacting genes: ADAM33 BTN3A2 CLEC2D CSGALNACT2 CXCL9 CYSRT1 EMP3 FAM209A GRM2 IGFBP5 IL27RA KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP4-12 LAT LNX1 LPAR3 MTDH NOTCH2NLA PIAS2 PLP1 TEX264 TJP1 TJP2 TMEM218 UBE2I WNK4	17 interacting genes: CDK6 CGN CLDN1 CLDN2 CLK1 CTNNA1 EPB41 HGS HSPB1 SAFB SCRIB SH3KBP1 SRPK2 TJP1 YWHAB YWHAG YWHAZ
Entrez ID		9075	9414
HPRD ID		06471	06369
Ensembl ID		ENSG00000165376	ENSG00000119139
Uniprot IDs		P57739	B7Z2R3 B7Z954 Q9UDY2
PDB IDs		4YYX	2OSG 3E17
Enriched GO Terms of Interacting Partners?
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