TMEM222 and PEX12

Data Source:
BioGRID (two hybrid)

		TMEM222	PEX12
Description		transmembrane protein 222	peroxisomal biogenesis factor 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Peroxisomal Importomer Complex
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding
	Biological Process		Protein Monoubiquitination Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Ubiquitination
Pathways			E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Alanine aminotransferase levels ( 31219225)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		38 interacting genes: ABHD16A AQP6 BIK BSCL2 CD79A CLDN5 CLRN1 COMT CRB3 CREB3 CREB3L1 EBP ELOVL4 ERG28 ERGIC3 EVI2B FAM174A FAM209A HIBADH HSD17B13 KIR2DL3 LMNA LRRC59 NCR3LG1 PEX12 PRSS23 PTGES RETREG3 RNASEK SLC10A1 SLC10A2 SSMEM1 STX1A TMEM14B TMEM35A TMPRSS2 TMX2 ZDHHC15	36 interacting genes: ACSL5 ADIPOQ BNIP2 BTN2A2 C5orf46 CLDN10 COL8A2 CXCL16 CYBC1 DNAJC30 ERMP1 FA2H FKBP8 FXYD6 GJB2 IER3IP1 MARCHF2 MGLL NKG7 NRM PEX10 PEX19 PEX5 PNLIPRP1 PTPN9 RBFA SEC22A SEC61G SMCO4 SRGN STX8 THSD7B TMEM11 TMEM222 TREX1 TTPA
Entrez ID		84065	5193
HPRD ID		13167	03455
Ensembl ID		ENSG00000186501	ENSG00000108733
Uniprot IDs		Q9H0R3	O00623
PDB IDs
Enriched GO Terms of Interacting Partners?
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