PEX12 and SEC61G

Data Source:
BioGRID (two hybrid)

		PEX12	SEC61G
Description		peroxisomal biogenesis factor 12	SEC61 translocon subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Peroxisomal Importomer Complex	Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Ssh1 Translocon Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding	Protein Binding Protein Transmembrane Transporter Activity P-P-bond-hydrolysis-driven Protein Transmembrane Transporter Activity
	Biological Process	Protein Monoubiquitination Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Ubiquitination	Posttranslational Protein Targeting To Membrane, Translocation Protein Targeting To ER
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Metabolite levels ( 23823483) Systemic lupus erythematosus ( 24871463) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		36 interacting genes: ACSL5 ADIPOQ BNIP2 BTN2A2 C5orf46 CLDN10 COL8A2 CXCL16 CYBC1 DNAJC30 ERMP1 FA2H FKBP8 FXYD6 GJB2 IER3IP1 MARCHF2 MGLL NKG7 NRM PEX10 PEX19 PEX5 PNLIPRP1 PTPN9 RBFA SEC22A SEC61G SMCO4 SRGN STX8 THSD7B TMEM11 TMEM222 TREX1 TTPA	10 interacting genes: AQP6 CREB3 CREB3L1 FAM209A LCN2 LRRC25 PEX12 SEC61A1 SFTPC TMEM51
Entrez ID		5193	23480
HPRD ID		03455	15318
Ensembl ID		ENSG00000108733	ENSG00000132432
Uniprot IDs		O00623	A0A024QYZ0 P60059
PDB IDs			6W6L
Enriched GO Terms of Interacting Partners?
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