PEX12 and STX8

Data Source:
BioGRID (two hybrid)

		PEX12	STX8
Description		peroxisomal biogenesis factor 12	syntaxin 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Peroxisomal Importomer Complex	Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Cytosol Integral Component Of Plasma Membrane Endomembrane System Integral Component Of Membrane SNARE Complex Late Endosome Membrane Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Monoubiquitination Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Ubiquitination	Intracellular Protein Transport Vesicle Fusion Endosome To Lysosome Transport Early Endosome To Late Endosome Transport Vesicle Docking Cellular Response To Interferon-gamma Regulation Of Protein Localization To Plasma Membrane
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Brain morphology (MOSTest) ( 32665545) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)
Interacting Genes		36 interacting genes: ACSL5 ADIPOQ BNIP2 BTN2A2 C5orf46 CLDN10 COL8A2 CXCL16 CYBC1 DNAJC30 ERMP1 FA2H FKBP8 FXYD6 GJB2 IER3IP1 MARCHF2 MGLL NKG7 NRM PEX10 PEX19 PEX5 PNLIPRP1 PTPN9 RBFA SEC22A SEC61G SMCO4 SRGN STX8 THSD7B TMEM11 TMEM222 TREX1 TTPA	83 interacting genes: ACVR1 AMIGO1 AQP2 ASGR2 BCL2L13 BIK BSND CALM1 CD300E CD79A CERS4 CLDN9 CLN8 COPA CPLX4 CREB3 CREB3L1 DHRS9 EBP ERGIC3 FAM174A FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GORAB GPR151 GPR152 GPR42 GPX8 JAGN1 JSRP1 KCNMB1 LMNA MCEE MCL1 MFF MGST2 MGST3 MMGT1 MS4A3 MTERF3 NAPA NAPG NCR3LG1 NDUFAF1 NDUFAF2 NSF PEX12 PSCA RETREG3 RNASEK SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC22A2 SSMEM1 STAR STMN4 STX1A STX2 STX4 STX5 STX7 TGFBR1 TMED8 TMEM14B TMEM179B TMEM205 TMEM237 TMEM86B TMPPE TMPRSS2 TSPAN12 VAMP5 VPS11 VPS18 VTI1B WDR91
Entrez ID		5193	9482
HPRD ID		03455	05012
Ensembl ID		ENSG00000108733	ENSG00000170310
Uniprot IDs		O00623	Q9UNK0
PDB IDs
Enriched GO Terms of Interacting Partners?
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